School of Medicine and Public Health

Courses

Clinical Laboratory Science
Physician Assistant
Anatomy
Biomolecular Chemistry
Biostatistics and Medical Informatics
Human Oncology
Medical Genetics
Medical History and Bioethics
Medical Microbiology and Immunology
Medical Physics
Medicine
Neuroscience Training Program
Oncology
Pathology and Laboratory Medicine
Pharmacology
Physiology
Population Health Sciences
Radiology

CLINICAL LABORATORY SCIENCE

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102 Introduction to Clinical Laboratory Science. I; 1 cr. Overview of medical technology and survey of specialty areas within the profession. P: Open to Fr.

310 Introduction to Clinical Laboratory Science Procedures. II or SS; 2 cr. Use or application of appropriate safety policies and procedures required for working in clinical or research laboratories. Proper collection of body fluids for analytical assessment; basic point of care laboratory testing procedures. P: Zoology 101, 102 & Chem 103.

404 Principles of Clinical Laboratory Instrumentation I. II; 3 cr (B-I). The basic electronic and computer principles used to build clinical laboratory instrumentation are discussed. Emphasis is placed on amplification of signals, digital logic, and computer control of instrumentation. P: CLS classification or cons inst.

410 Basic Cytology and Laboratory Procedures. I; 1 cr. A comprehensive review of cellular biology, the study of optical methods with emphasis on the light microscope and the various techniques used in preparation and staining of specimens for cytologic and histologic study. P: Stdt must be enrolled in the cytotechnology internship prgm at the WI State Lab of Hygiene.

510 Advanced Laboratory Procedures. SS; 1 cr. Preparation of non-gynecologic cytologic specimens using several different instrument methodologies. Application of universal precautions and safety in the handling of unknown biologic hazards. Introduction to histologic preparatory techniques and special staining methods. P: Stdt must be enrolled in the cytotechnology internship prgm at the WI State Lab of Hygiene.

514 Hemostasis and Coagulation. II; 2 cr (B-D). Platelet function, coagulation factors and study of hemorrhagic disorders. P: CLS classification or cons inst.

515 Clinical Hematology I. I; 3 cr. The origin, morphology, and function of normal hematopoietic cells; assessment of peripheral blood and body fluids are assessed for red cell mass, hemoglobin content, quantity of blood cells and white cell identification. Correlation of laboratory data with normal metabolic processes. P: CLS classification or cons inst.

516 Clinical Hematology II. II; 3 cr. Continuation of Clinical Hematology I; principles and procedures to identify abnormal hematopoietic cells according to degree of maturation. Correlation of laboratory data with metabolic processes and disease states. P: CLS classification, Clnlabsc 515 or cons inst.

520 Selection and Evaluation of Measurement and Control Procedures. II; 3 cr. Selection of diagnostic tests, evaluation of measurement procedures, including statistical analysis of experiments, and procedures for quality control of measurements. P: CLS classification or cons inst.

525 Clinical Chemistry I. I; 3 cr. Covers principles and procedures to measure selected clinical chemistry analytes and hormones and the correlation of laboratory data with metabolic processes and disease states. P: CLS classification or cons inst.

526 Clinical Chemistry II. II; 3 cr. This course is a continuation of Clinical Chemistry I and covers principles and procedures used to measure selected clinical chemistry analytes, therapeutic drugs, drugs of abuse, and the correlation of laboratory data with metabolic processes and disease states. P: CLS classification or cons inst.

535 Laboratory Diagnosis of Infectious Diseases I. I; 3 cr. Principles and practices of microbiology in the diagnosis and therapy of infectious diseases in humans. P: CLS classification or cons inst.

536 Laboratory Diagnosis of Infectious Diseases II. II; 3 cr. Continuation of Laboratory Diagnosis of Infectious Diseases I; principles and practices of mycology, virology and parasitology in the diagnosis and therapy of infectious diseases in humans. P: CLS classification or cons inst.

540 The Female Reproductive System. I; 8 cr. Anatomy, histology, physiology, and pathology of the female reproductive tract and the corresponding cellular manifestations which provide diagnostic information. Cellular changes due to therapy and specimen collection. Correlation of the didactic information with the microscopic cellular patterns to provide a diagnosis. P: Stdt must be enrolled in the cytotechnology internship prgm at the WI State Lab of Hygiene.

541 Clinical Practice I. I; 1 cr. Clinical practicum to develop diagnostic expertise involving the microscopic examination of routine gynecologic specimens (Pap smears). Observe the signout of abnormal cytologic specimens by cytopathologist staff. P: Stdt must be enrolled in the cytotechnology internship prgm at the WI State Lab of Hygiene.

543 The Respiratory System. I; 3 cr. Anatomy, histology, physiology and pathology of the respiratory tract and the corresponding cellular manifestations which provide diagnostic information. Cell changes related to specimen processing. Correlation of the didactic information with the microscopic cellular patterns to provide a diagnosis. P: Stdt must be enrolled in the cytotechnology internship prgm at the WI State Lab of Hygiene.

544 The Breast. I or II; 1 cr. Anatomy, histology, physiology and pathology of the breast and the corresponding cellular manifestations which provide diagnostic information. Cell changes related to specimen processing. Correlation of the didactic information with the microscopic cell patterns to provide a diagnosis. P: Stdt must be enrolled in the cytotechnology internship prgm at the WI State Lab of Hygiene.

545 The Genitourinary System. II; 2 cr. Anatomy, physiology, histology and pathology of the urinary tract and male reproductive systems and the corresponding cellular manifestations which provide diagnostic information. Cell changes related to specimen processing. Correlation of didactic information with microscopic cell patterns to provide a diagnosis. P: Stdt must be enrolled in the cytotechnology internship prgm at the WI State Lab of Hygiene.

546 The Gastrointestinal System. II; 3 cr. Anatomy, histology, physiology and pathology of the gastrointestinal system and the corresponding cellular manifestations which provide diagnostic information. Cell changes related to specimen processing. Correlation of the didactic information with the microscopic cellular patterns to provide a diagnosis. P: Stdt must be enrolled in the cytotechnology internship prgm at the WI State Lab of Hygiene.

547 Effusions. II; 2 cr. Anatomy, physiology, histology and pathology of the body cavities. Cytologic manifestations which provide diagnostic information. Cell changes related to specimen processing. Correlation of the didactic information with the microscopic cellular patterns to provide a diagnosis. P: Stdt must be enrolled in the cytotechnology internship prgm at the WI State Lab of Hygiene.

548 The Central Nervous System. II; 1 cr. Anatomy, physiology, histology and pathology of the central nervous system and the corresponding cellular manifestations which provide diagnostic information. Cell changes related to specimen preparation. Correlation of the didactic information with the microscopic cellular patterns to provide a diagnosis. P: Stdt must be enrolled in the cytotechnology internship prgm at the WI State Lab of Hygiene.

549 Miscellaneous Systems. II; 3 cr. Anatomy, histology, physiology and pathology of skin, thyroid, lymph nodes and other sites and the corresponding cellular manifestations which provide diagnostic information. Emphasis on specimen collection by fine needle aspiration. Correlation of the didactic information with the microscopic cellular patterns to provide a diagnosis. P: Stdt must be enrolled in the cytotechnology internship prgm at the WI State Lab of Hygiene.

550 Clinical Immunohematology. I; 3 cr. Study of human blood groups, Rh factors; pretransfusion testing, antibodies, transfusion reactions and problem solving. P: CLS classification or cons inst.

551 Advanced Clinical Practice. SS; 8 cr. Clinical practicum to develop diagnostic expertise of cytologic specimens. Examine challenging cases with emphasis on diagnostic pitfalls. Observe patient clinics related to cytologic specimen collection. Participate at clinical experiences in fine needle aspiration, histology, and a private cytology laboratory. P: Stdt must be enrolled in the cytotechnology internship prgm at the WI State Lab of Hygiene.

560 Clinical Immunology and Applied Techniques. I; 3 cr (B-I). The structure and function of the human immune system. Concepts and theories of the immune response. Principles and procedures of antigen-antibody antigen-antibody reactions, immunochemical techniques with emphasis on clinical application in the evaluation of the immune status and the diagnosis of infectious diseases and immune disorders. P: CLS classification or cons inst.

570 Molecular Diagnostics. II; 2 cr. Principles and laboratory skills required to apply molecular biology techniques to disease diagnosis. P: Bmolchem 503/504, CLS classification or cons inst.

573 Applied Cytology I. II; 1 cr. Written and practical application of the comprehensive body of knowledge to all aspects of preparation, evaluation, correlation and diagnosis of cytologic specimens. P: Stdt must be enrolled in the cytotechnology internship prgm at the WI State Lab of Hygiene.

574 Applied Cytology II. SS; 1 cr. Written and practical application of the advanced comprehensive body of knowledge to all aspects of preparation, evaluation, correlation and diagnosis of cytologic specimens. Practice in nationally offered cytologic examinations. P: Stdt must be enrolled in the cytotechnology internship prgm at the WI State Lab of Hygiene.

575 Clinical Laboratory Science Practicum. I or II or SS; 1-6 cr. A practicum experience with opportunities to apply classroom knowledge and training and acquire additional skills in an actual clinical laboratory science setting. P: CLS classification or cons inst.

610 Seminar in Clinical Cytogenetics. SS; 1 cr. Overview of the basic features of chromosome structure and behavior including karyotyping clinical correlates of numerical and structural chromosome aberrations, sex chromosome abnormalities, breakage syndromes and the chromosomal changes associated with the development of cancer. P: Stdt must be enrolled in the cytotechnology internship prgm at the WI State Lab of Hygiene.

620 Management Seminar. I; 1 cr. Management philosophy and procedures as they relate to the function of a clinical laboratory. Topics addressed include: organizational hierarchy, leadership styles, budgetary decision making, personnel and ethical issues, and communication techniques. P: CLS classification or cons inst.

625 Seminar in Laboratory Operations and Quality Control. SS; 1 cr. Review the fundamentals of basic administrative functions and regulatory requirements including planning, organizing, supervising and controlling business management, record keeping, data processing and laboratory safety. Quality assurance procedures necessary for obtaining, processing, diagnosing and reporting cytologic specimens. P: Stdt must be enrolled in the cytotechnology internship prgm at the WI State Lab of Hygiene.

630 Seminar in Clinical Cytology. SS; 1 cr. Preparation of a case study or clinical topic of choice by each student to present to a peer professional group of cytology staff and medical faculty. Preparation of a referenced scientific term paper or participation in an approved research or class project pertaining to clinical cytology. P: Stdt must be enrolled in the cytotechnology internship prgm at the WI State Lab of Hygiene.

640 Current Issues Seminar. II; 1 cr. Current and emerging issues that impact on the clinical laboratory scientist, federal legislation, health care delivery systems, advances in testing technologies, etc. P: CLS classification or cons inst.

PHYSICIAN ASSISTANT

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348 Theories and Practice in Emergency Care. I; 1 cr. Knowledge, attitudes and skills needed to evaluate and initiate care for acutely ill and/or injured persons. P: Jr st in the Physician Assistant program or cons inst.

400 Clinical Medicine for Physician Assistants I. I; 5 cr. An introduction to the knowledge and skills needed to diagnose and treat patient health problems. P: Jr st, Physician Assistant majors or cons inst.

401 Clinical Medicine for Physician Assistants II. (Crosslisted with Phm Prac) II; 5 cr. Continuation of 400. P: Jr st. Phy Asst major or Pharm D major.

402 Pediatrics for Physician Assistants I. SS; 1 cr. Introductory pediatrics course covering problems encountered in the general pediatric population and reinforcing basic primary care clinical principles. Weekly lectures complementing material presented in concurrent PA 400. P: Jr st, Phy Asst or cons inst.

403 Pediatrics for Physician Assistants II. SS; 1 cr. Continuation of PA 402. P: Jr st, Phy Asst or cons inst.

416 Issues in Professional Practice for Physician Assistants. II; 1 cr. Introduction to issues related to the physician assistant profession. Emphasis on developing an understanding of health care systems and the role of the physician assistant. P: Jr st in the Phy Asst Program.

419 Patient Assessment: History and Physical Examination for PAs. SS; 3 cr. Provides the primary care physician assistants with the knowledge and physical exam skills to evaluate patients in a variety of settings. Normal and pathological physical findings are discussed. Students master interview skills and physical exam skills applicable to all patients. Selected physical exam techniques are emphasized. P: Pa-3 or Pa-4 classification; or cons inst.

420 Advanced Patient Evaluation in the Primary Care Setting I. I; 1 cr. Advanced physical examination and patient evaluation techniques with an emphasis on the musculoskeletal system; selected physical exam procedures in the complete evaluation of patients; advanced medical interviewing skills. P: Phy Asst 419.

421 Advanced Patient Evaluation in the Primary Care Setting II. II; 2 cr. Advanced physical examination and patient evaluation techniques; regional physical examinations; radiology; advanced evaluation of heart sounds. P: Phy Asst 420.

422 Field Experience in Patient Assessment. SS; 2 cr. P: Phy Asst 421.

430 Obstetrics and Gynecology for Physician Assistants. I; 2 cr. Provides Physician Assistant (PA) students a theoretical and clinical background for the assessment, diagnosis and management of problems in obstetrics and gynecology. P: Jr st in Phy Asst Program.

440 Laboratory Medicine for Physician Assistants. II; 2 cr. This course emphasizes the utilization of laboratory methods for the diagnosis and treatment of disease. The content focuses on those aspects pertinent to the provision of ambulatory, primary care. P: Jr st, Phy Asst or cons inst.

448 A Team Approach to Emergency Care. (Crosslisted with Medicine, Nursing, Phm Prac) II; 3-4 cr. Concepts and skills related to the provision of advanced emergency medical care, in primary and secondary settings, by a health care team. P: PA classification or cons inst.

470 Surgical Principles and Procedures. SS; 1 cr. An introduction to the role of the Physician Assistant in surgery; surgical procedures commonly performed in general surgery; pre- and post-operative care; or technique; an introduction to the surgical literature. P: PA 400, PA 401.

516 Contemporary Professional Issues—Physician Assistants. II; 1 cr. Information course for senior physician assistant students in areas of certification and registration, employment, economics, profession organizations and political/legislative topics. P: Sr st in the Phy Asst Program.

600 Interdisciplinary Rural Primary Health Care Practice. (Crosslisted with Nursing, Phm Prac, Soc Work) I; 2 cr (D). Using a framework of interdisciplinary health care teams and community-based practice models, the course focuses on the provision of primary health care services in rural and underserved populations. P: Sr st in a health professions prgm e.g. nurs, phy asst, pharm, soc wrk, med, nutr, occ ther, phy ther or cons inst.

629 Physician Assistant Surgery Preceptorship. I, II; 8 cr. An eight week intensive clinical learning experience with an emphasis in surgery and taking place in a variety of off-campus clinical settings under the direction of a supervising physician preceptor. P: Sr st in Phy Asst Program.

639 Physician Assistant Primary Care Preceptorship. I, II; 8 cr. An eight week intensive clinical learning experience with an emphasis in primary care medicine and taking place in a variety of off-campus clinical settings under the direction of supervising physician preceptors. P: Sr st in Phy Asst Program.

649 Physician Assistant Internal Medicine Preceptorship. I, II; 8 cr. An eight week intensive clinical learning experience with an emphasis in internal medicine and taking place in a variety of off-campus clinical settings under the direction of a supervising physician preceptor. P: Sr st in Phy Asst Program.

699 Independent Study. I, II, SS; 1-3 cr (A). P: Cons inst.

ANATOMY

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328 Human Anatomy. II; 3 cr (B-E). Lectures. Structure of the human body. P: Admission to professional curric in nursing, pre-nursing, or pre-physician assistant program.

329 Human Anatomy—Kinesiology. II; 2 cr (B-I). P: Kinesiology major; kinesiology majors must take Anatomy 328 prior to or concurrent with Anatomy 329. Required for dance-related majors. Open to Fr.

333 Anatomy for Medical Sonographers. Even yrs.; SS; 1 cr. Dissection and study of human anatomy relevant to Medical Sonography students. P: Admission to Med Sonography Prgm.

429 Human Anatomy Laboratory for Physician Assistants. SS; 5 cr. Prosected specimens and some supervised dissection. P: Admission to phy asst professional curric or cons inst.

575 The Biological Processes of Aging. (Crosslisted with Pop Hlth) II; 3 cr (B-I). Lecture. Theories and mechanisms of the aging process with special reference to biological changes within and between cultures. Studies of decreasing ability to adapt to environment with age, due to anatomical and physiological changes in the human body, organ systems, cellular and molecular levels. P: Jr st, 2 sems of chem, gen biol or zool, intro physiol or cons inst.

611 Systems Neuroscience. (Crosslisted with Neurosci, Phmcol-M, Physiol, Psych) II; 4 cr (A). Introduction to the anatomy and physiology of the mammalian nervous system. Lectures will cover the neuroanatomy of the major subdivisions of the human brain, the major sensory and motor systems, and higher order functions. Lab/discussion sections will emphasize readings from the primary literature and hands-on dissections. P: Physiol 610.

619 Microscopy of Life. (Crosslisted with Physics, BME, Chem, Med Phys, Phmcol-M, Radiol) II; 3 cr (I). Survey of state of the art microscopic, cellular and molecular imaging techniques, beginning with subcellular microscopy and finishing with whole animal imaging. P: 2nd semester intro physics including light & optics (e.g. 104, 202, 208) or cons inst.

622 Human Anatomy—Physical Therapy, Occupational Therapy. SS; 6 cr (B-I). Gross human anatomy involving complete dissection of the human body. Special emphasis is placed on the musculoskeletal and peripheral nervous systems, and living subject and surface anatomy. P: Admission to phys or occ therapy professional program, or cons inst.

630 Neuronal Mechanisms for Sensation and Memory in Cerebral Cortex. (Crosslisted with Neurosci, Physiol) Alt yrs.; II; 3 cr (B-D). Current literature will be considered in lectures and discussions that provides insight into how the cerebral cortex processes sensory information to generate and store cogent representations of the external world. The course includes laboratory exercises and demonstrations. P: Intro neurosci crse highly recommended: Neurosci/Anat/Phmcol/Physiol 611, Med Sc-M 731, Comp Bio 505, Zool/Neurosci/Psych 523, Psych/Neurophy/Neurosci/Zool 524; or cons inst.

637 Functional Neuroanatomy. I; 3 cr (B-I). For physical therapy and occupational therapy majors. Motor and sensory systems under normal and altered conditions. P: Anatomy 622 with grade of C or better or cons inst.

660 Electron Microscopy: Theory & Practice. (Crosslisted with Ahabs, An Sci) Even yrs.; SS; 3 cr. P: Cons inst.

675 Topics in Anatomy. I, II, SS; 1-3 cr. Special topics in anatomy. See footnote in Timetable for specific topic. P: Vary according to topic.

699 Independent Study. I, II, SS; 1-4 cr (A). P: Cons inst.

BIOMOLECULAR CHEMISTRY

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314 Introduction to Human Biochemistry. I, SS; 3 cr (P-I). Lectures and conferences on introductory aspects of biological chemistry with an emphasis on providing a broad overview of both basic and clinical aspects of human biochemistry for health professionals. P: Chem 104 or 108 or equiv.

503 Human Biochemistry. II; 3 cr (B-A). Lectures and conferences on basic principles of biological chemistry with emphasis on its application to the medical sciences. P: Chem 341 or 343 or cons inst.

504 Human Biochemistry Laboratory. II, SS; 2 cr (B-A). Lab and conferences on basic principles of biological chemistry with emphasis on general methods and techniques. P: Bmolchem 503 or Biochem 501 or equiv; 503 may be taken con; or cons inst.

668 Microbiology at Atomic Resolution. (Crosslisted with Microbio) II; 3 cr (B-D). Three-dimensional protein structures form the basis for discussions of high resolution microbiology; how particular problems are solved with given protein architectures and chemistries and how themes of protein structure are modified and recycled. P: Biochem (e.g. Biochem 501), molecular biol (e.g. Bact 526 or 612) required, one semester of physical chem preferred.

675 Advanced or Special Topics in Biomolecular Chemistry. I or II or SS; 1-3 cr (B-A). P: Cons inst.

699 Special Research Problems. I or II or SS; 1-6 cr (A). Conferences. P: Cons inst.

BIOSTATISTICS AND MEDICAL INFORMATICS

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511 Introduction to Biostatistical Methods for Public Health. I; 3 cr. Provides breadth in biostatistical methods for public health practitioners. Topics will include research design, data collection methods and database management, statistical computing and programming, descriptive statistics in tables and graphics, introductory statistical methods, and survey sampling. P: Enrollment in the Master of Public Health (MPH) progm at UW-Madison or cons inst.

541 Introduction to Biostatistics. (Crosslisted with Stat) I; 3 cr (r-N-I). Course designed for the biomedical researcher. Topics include: descriptive statistics, hypothesis testing, estimation, confidence intervals, t-tests, chi-squared tests, analysis of variance, linear regression, correlation, nonparametric tests, survival analysis and odds ratio. Biomedical applications used for each topic. P: Math 221 or equiv or cons inst.

542 Introduction to Clinical Trials I. (Crosslisted with Stat) II; 3 cr (I). Intended for biomedical researchers interested in the design and analysis of clinical trials. Topics include definition of hypotheses, measures of effectiveness, sample size, randomization, data collection and monitoring, and issues in statistical analysis. Statistics graduate students should take Stat 641. P: Stat 541 or equiv or cons inst.

544 Introduction to Clinical Trials II. I; 3 cr. Intended for biomedical researchers, focuses on design, implementation, and conduct of clinical trials. Topics include: regulatory requirements; data collection; data quality and management; budgets; federal, institutional, and sponsor-defined requirements; establishment of research infrastructures; preparation of investigator-INDs; investigator responsibilities. P: BMI 541 or equiv & BMI 542 & cons inst.

546 Practicum in Clinical Trial Data Analysis and Interpretation. (Crosslisted with Stat) II; 3 cr (I). Provides practice in analysis and interpretation of existing datasets from national and international clinical trials in a variety of diseases. Students will develop a research question, review clinical protocols, and analyze available data to prepare a report. P: Stat 541 or 572 & Stat 542 or 641.

576 Introduction to Bioinformatics. (Crosslisted with Comp Sci) I; 3 cr (A). Algorithms for computational problems in molecular biology. The course will study algorithms for problems such as: genome sequencing and mapping, pairwise and multiple sequence alignment, modeling sequence classes and features, phylogenetic tree construction, and gene-expression data analysis. P: Comp Sci 367, Math 222.

643 Practicum in Coordinating Center Methods. (Crosslisted with Stat) SS; 3 cr (A). Practicum in the operation of a coordinating center in a clinical trial or epidemiologic study. Covers organization, randomization, forms design and collection, quality control and other operational responsibilities of coordinating centers. P: Stat 641 or 642 or cons inst.

699 Independent Study. I, II, SS; 1-3 cr (A). Directed study to pursue knowledge beyond curriculum. P: Jr st or cons inst.

HUMAN ONCOLOGY

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410 Radiobiology. (Crosslisted with Med Phys) Even yrs.; II; 2-3 cr (B-E). Effects of ionizing radiations of living cells and organisms, including physical, chemical, and physiological bases of radiation cytotoxicity, mutagenicity, and carcinogensis; lecture and lab.

501 Radiological Physics and Dosimetry. (Crosslisted with Med Phys, Physics, BME) I; 3 cr (A). Interactions and energy deposition by ionizing radiation in matter; concepts, quantities and units in radiological physics; principles and methods of radiation dosimetry. P: Calculus and modern physics.

510 Topics in Oncology. Odd yrs.; II; 1-3 cr. As a topics course in human oncology, the topics will vary. P: Undergrad basic math or physics or basic biology or pharmacology or M.D.

699 Independent Study in Human Cancer Biology. I, II, SS; 1-3 cr (A). Tutorial lab/library research and study. Opportunity for learning in depth without a thesis requirement. Maximum cumulative credits: 9. P: Human Onc 402 and/or cons inst.

MEDICAL GENETICS

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565 Human Genetics. (Crosslisted with Genetics) I; 3 cr (B-I). Principles, problems, and methods of human genetics. Surveys aspects of medical genetics, biochemical genetics, molecular genetics, cytogenetics, quantitative genetics, and variation as applied to humans. P: Genet 466 or equiv or cons inst.

646 Cancer Genetics. Odd yrs.; II; 2 cr. Provides students with a background in cancer genetics from a medical, biologic, and clinical perspective. P: Enrollment in the Genetic Counseling Training Program or cons inst.

677 Advanced Topics in Genetics. (Crosslisted with Genetics) I, II, SS; 1-3 cr (B-A). Contents vary; consideration of subjects not included in the curriculum. P: Cons inst or Grad st.

699 Independent Reading. I, II, SS; 1-3 cr (A). P: Cons inst & Sr st.

MEDICAL HISTORY AND BIOETHICS

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212 The Physician in History. (Crosslisted with Hist Sci) I or II; 3 cr (H-E). The healer's role in medical care and society from antiquity to the twentieth century. Physician, patient and social relationships; changing disease theories and therapeutic procedures; creation of varied institutional frameworks for medicine and public health. P: Open to Fr. For honors credit con reg in Hist Sci/Hist Med 284 or cons inst.

218 History of Twentieth Century American Medicine. (Crosslisted with Hist Sci) Irr.; 3 cr (S-E). This undergraduate lecture course introduces students to the development of the modern American medical care system. P: Open to Fr.

275 Science, Medicine, and Race: A History. (Crosslisted with Afroamer, Hist Sci) Alt yrs.; I; 3 cr (e-Z-E). Surveys the medical and scientific constructions of categories of race, placing the development of racial theories in a broad social and political context. The course will pay particular attention to the importance of racial science in slavery and colonialism. P: Open to Fr.

284 Physician in History (Honors). (Crosslisted with Hist Sci) I or II; 1 cr (H-E). Honors course for students enrolled concurrently for honors in History of Science 212. Open to non-honors students with consent of instructor. P: Con reg for honors in Hist Sci/ Hist Med 212 or cons inst. Open to Fr.

331 Science, Medicine and Religion. (Crosslisted with Hist Sci, Relig St) Irr.; 3-4 cr (H-D). Science, medicine and religion from antiquity to the present, with emphasis on Western civilization. P: Jr st and cons inst.

333 History of Modern Biology. (Crosslisted with Hist Sci) I or II; 3 cr (H-D). Survey of major developments in biology and related sciences ca. 1700-1950. Topics include morphology and embryology; evolutionary theory, ecology, and genetics; physiology and recent experimental biology. P: Jr st or cons inst.

394 Science in America. (Crosslisted with Hist Sci, History) Irr.; 3 cr (H-D). From the colonial period to the present; emphasis on the development of scientific institutions and the influence of science on American life. P: Jr st or cons inst.

431 Childbirth in the United States. (Crosslisted with Women St, Hist Sci) II; 3 cr (S-D). American women's childbirth experiences from the colonial period to the present. Childbirth as a cultural as well as a biological event. Basic physiological information for understanding and evaluating changing approaches to pregnancy and childbirth. P: Women St 103 or 430 or equiv; or cons inst.

444 Health and Social Welfare in Western Society. (Crosslisted with Hist Sci, Geog) Irr.; 3 cr (H-I). The rise of public concern for human well-being in the European nations from preliterate society to the twentieth century. Greek individualism and Christian charity, the shift from ecclesiastical to secular responsibility, the sanitary movement and development of a scientific basis for public health, and emergence of contemporary public health issues. P: So st.

504 Society and Health Care in American History. (Crosslisted with History, Hist Sci) I or II; 3 cr (B-I). Lecture-seminar. Health care in America since the colonial period; emphasis on social developments. P: Jr st & cons inst.

507 Health, Disease and Healing I. (Crosslisted with History, Hist Sci) I or II; 3-4 cr (H-I). Medicine in Europe from antiquity to the 18th century, investigating changes in medical ideas, institutions, practices, and organization. P: Jr st.

508 Health, Disease and Healing II. (Crosslisted with History, Hist Sci) I or II; 3-4 cr (H-I). Medicine in Europe from the 18th century to mid-20th century, investigating changes in disease and demography, state interest in health care, the medical professions, and both scientific and alternative medical ideas. P: Jr st.

509 The Development of Public Health in America. (Crosslisted with Hist Sci) I or II; 3 cr (B-I). Seminar. Health problems in the U.S. from the colonial period to the twentieth century; efforts made toward their solutions. P: Jr st & cons inst.

513 Environment and Health in Global Perspective. (Crosslisted with Hist Sci, Envir St) II; 3 cr (Z-A). Explores the historical relationships between environmental change and human health from the 17th through the 20th century. Topics include colonialism and disease, medical geography, urban pollution and reform, workplace hazards, environmental risk, and the anti-toxics and environmental justice movements. P: Jr st.

523 Race, American Medicine and Public Health. (Crosslisted with Afroamer, Hist Sci) Irr.; 3 cr (e-S-D). The course will provide historical perspectives on current dilemmas facing black patients and health care professionals. P: Jr or Sr st.

524 The Medical History of Sex and Sexuality. (Crosslisted with Hist Sci, Women St) Alt yrs.; II; 3 cr (H-I). Examines the changing place of medicine and scientific authority in public and private sexual lives. Highlights the role of medicine in defining appropriate sexual behavior, understanding the cause of sexual deviance, and treating sexual problems and diseases. P: Prev history (incl med hist & hist sci) course preferred.

531 Women and Health in American History. (Crosslisted with Women St, Hist Sci) I or II; 3 cr (B-I). Women as patients and as health professionals in America from the colonial period to the present. P: Jr st & cons inst.

532 The History of the (American) Body. (Crosslisted with Women St, Hist Sci) Alt yrs.; I; 3 cr (H-A). This course demonstrates that human bodies have social and cultural histories. It will highlight the social values placed on different bodies, the changing social expectations bodies create, and the role of science and medicine in creating the cultural meanings of bodies. P: Women St 103 or other women's studies crse required; prev hist (incl med hist & hist sci) crse preferred.

543 Doctors and Delusions: Madness and Medicine in the Modern Era. (Crosslisted with History, Hist Sci) I; 3 cr (Z-I). Medical approaches to mental illness from 1750 to the present. Emphasis on how tension between biomedical and socio-environmental theories about psychopathology have marked modern psychiatry. Focus on Europe and the United States with global and comparative dimensions. P: Jr st or cons inst.

545 Ethical and Regulatory Issues in Clinical Investigation. I; 1 cr (A). This course will explore and examine the ethical issues central to clinical research, regulations governing clinical investigation, and the role of good clinical practice for clinical trials.

553 International Health and Global Society. (Crosslisted with Hist Sci, Pop Hlth) I; 3 cr (Z-I). Major problems in international health from 1750 to the present. Focus on disease epidemiology and ecology; political economy of health; migration; quarantine; race, ethnicity, and health care; international health research; cross-cultural healing; mental and maternal health; growth of international health organizations. P: Jr or Sr st, or cons inst.

558 Ethical Problems Raised by Biomedical Technology. (Crosslisted with Philos) II; 3 cr (H-I). Ethical issues apparently created by new biomedical technologies, such as genetic screening, prenatal diagnosis, prolongation of life, treatment of severe birth defects, in vitro fertilization, behavior modification, psychosurgery, and transplantation. P: Jr st or cons inst.

559 Topics in Ethics and History of Medicine. Irr.; 3 cr (H-D). A survey of ethical and social issues in medical ethics and history of medicine. Cooperating faculty may be drawn from philosophy, law, medical ethics, history, political science, public health, economics, education, and communication, as well as medicine and the biological sciences. P: Cons inst; enrollment may be limited depending on topic and approach.

560 Task Force in Bioethics Policy. Irr.; 3 cr (S-A). Simulated public policy task force, charged to address the ethical, legal, social and public policy challenges posed by a major topic in contemporary bioethics. Significant individual and group writing required. P: Prerequisites may vary according to topic. Jr or Sr st and cons inst based on relevant prior coursework.

561 Greek and Roman Medicine and Pharmacy. (Crosslisted with S&A PHM, Classics, History, Hist Sci) I; 3 cr (H-D). Greek and Roman medicine and drug lore from the Pre-Socratics to Oribasius (c. 600 B.C.- A.D. 350), including the backgrounds of ancient Egyptian and Mesopotamian medicine. P: Jr or Sr st, or cons inst.

562 Byzantine Medicine and Pharmacy. (Crosslisted with S&A PHM, History, Hist Sci, Medieval) II; 3 cr (H-D). Byzantine and Islamic medicine and drug lore from Oribasius to the beginnings of the Italian Renaissance (c. 350- c. 1400 A.D.). P: Jr or Sr st or cons inst.

565 The Ethics of Modern Biotechnology. (Crosslisted with Agronomy, Philos, Rur Soc) I or II; 3-4 cr (H-I). Study of ethical issues arising from the application of modern biotechnology to microorganisms, crops, and non-human animals. Readings cover moral theory, technology studies, political philosophy, the science used in biotechnology, and current regulations governing its use. P: Jr st & cons inst.

575 Clinical Medicine Since 1750. (Crosslisted with Hist Sci) Irr.; 3 cr (B-D). Lecture-Seminar. Development of clinical medicine in Europe and America from the eighteenth to the twentieth century. P: Jr st & cons inst. Previous hist of medicine crse desirable.

613 Jewish Law and Ethics in Comparative Perspective. (Crosslisted with Jewish, Relig St) I or II or SS; 3 cr (Z-D). History, sources and methods of Jewish Law reflecting the diversity of Jewish life and culture. Topical focus on family law, the role and status of women, and bioethical issues. Some comparisons with other systems of religious law, secular law and secular philosophical ethics. P: Jr st; some prior coursework in Jewish studies, law or both, or cons inst.

668 Topics in History of Medicine. (Crosslisted with Hist Sci) I or II or SS; 3 cr (A). Upper-level special topics course in the history of medicine. P: Jr st.

699 Independent Study in Medical History. I or II or SS; 1-3 cr (A). P: Jr st & cons inst.

MEDICAL MICROBIOLOGY AND IMMUNOLOGY

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301 Pathogenic Bacteriology. I; 2 cr (B-I). Lectures on medically important bacteria, emphasizing the process of pathogenesis and host/parasite interactions, as well as intervention strategies, immunity and genetics as they apply to the pathogens. Open to non-majors. P: MM&I 341 (or con reg), 2 sem intro biol w/lab or Biocore series 301-304; 1 sem org chem; or cons inst.

302 Medical Microbiology Laboratory. I; 3 cr (B-I). Lab covering procedures and aseptic techniques for isolation and identification of pathogenic microorganisms (bacteria, fungi, and viruses). P: 2 sem intro biol w/lab or Biocore series 301-304; prev or con reg in MM&I 301 or equiv.

341 Immunology. I, II; 3 cr (B-I). Lecture, discussion. An introduction to the immune response to infectious disease. Examines the role of the host in host-parasite relationships using select microbial agents or antigens to illustrate the nonspecific and specific mechanisms of host defenses. Includes study of the nonspecific inflammatory response, the nature of microbial antigens, current concepts of antibody and cell-mediated immune reactions to infectious agents and the principles underlying the development of vaccines. P: HS biol, chem, 1 sem of college biol; So st; to receive cr for both MM&I 341 & 528, MM&I 341 must be completed first.

350 Parasitology. (Crosslisted with Zoology, Ahabs) II; 3 cr (B-I). General biology, ecology and phylogeny of animal parasites, including those of humans; host-parasite interactions; general epidemiological principles of parasitic infections. P: Intro course in biology, So st.

351 Parasitology Laboratory. (Crosslisted with Zoology, Ahabs) II; 2 cr (B-I). Optional laboratory component of Zoology/Med Micro/Ahabs 350. Emphasis on experiments involving live animal parasites, including: trematodes, tapeworms, gapeworms, hookworm, ascarids, trichina, filaria, trypanosomes, coccidia, and malaria. P: Con reg in Zoology/MM&I/Ahabs 350.

410 Medical Mycology. II; 2 cr (B-A). Lectures and discussions. Pathogenesis, molecular biology, host-parasite interactions, immunology, epidemiology, and diagnosis of systemic, subcutaneous, and superficial fungal infections. P: 2 sem intro biol w/lab or Biocore series 301-304; a crse in immunology or cons inst.

412 Medical Mycology Laboratory. II; 1 cr (B-A). Laboratories and discussions on the ecology, sample collection, culture techniques and identification of medically important mycotic microorganisms. This is a companion lab to MM&I 410. Priority given to MM&I majors. P: MM&I 301 & 302 & con reg in MM&I 410.

460 Techniques in DNA Science for Microbiologists. SS; 3 cr (I). Introduction to recombinant DNA techniques commonly used in prokaryotic research and clinical Microbiology laboratories. Topics include DNA isolation, agarose gel electrophoresis, restriction enzyme digestion of DNA, ligation, transformation, Southern blotting and PCR. Students are required to work independently. P: Jr st, Chem 221 or 110 or equiv, bact lecture & lab, & cons inst. Preference given to MMI undergrad majors.

504 Infectious Diseases of Human Beings. I; 3 cr (A). Pathogenesis, clinical descriptions, and prevention. Primarily for Physician Assistant, Pharmacy, and Nursing students. P: A course in microbiology. Not for MM&I majors.

528 Immunology. (Crosslisted with Ahabs, Microbio) I; 3 cr (I). Development and functions of immune response in animals; a comprehensive study of experimental humoral and cellular immunity. P: Two sem chem and one sem zoology or gen biology.

529 Immunology Laboratory. (Crosslisted with Ahabs) II; 2 cr (I). Selected techniques illustrating concepts of cellular and humoral immunity as a supplement to Immunology 528. P: Two sem of chem and one sem of zoology or gen biology. Jr or Sr st; cons inst.

554 Emerging Infectious Diseases and Bioterrorism. I; 2 cr (A). Identification of analysis and solution of emerging infectious disease problems and the problems of bioterrorism. P: MM&I 301 or cons inst.

575 Biology of Viruses. (Crosslisted with Biochem) II; 2 cr (A). Lecture-discussion. Broad coverage of animal virology taught at molecular level. Topics include virus structure, viral replication/lifecycle, aspects of pathogenesis and prevention. P: Biocore 301/302, or AP score of 4 or 5 and Zoology 151 or 152; or MM&I 301.

603 Clinical and Public Health Microbiology. (Crosslisted with Pop Hlth) II; 5 cr (I). Lecture-seminar sessions. Lectures (44) describe microorganisms of clinical and public health significance. Seminar sessions (14) discuss issues and controversies of specimen receiving and processing, bacteremia, serodiagnosis of infectious agents, antimicrobial susceptibility testing, laboratory management, and novel approaches to detect infectious agents. P: MM&I 301 & 302 or equiv.

655 Biology and Genetics of Filamentous Fungi. (Crosslisted with Pl Path, Microbio, Botany, Genetics) Odd yrs.; II; 3-4 cr (A). Fungal genetics, genomics, and physiology using plant pathogenic fungi and the genetic models Aspergillus nidulans and Neurospora crassa as model systems to explore the current knowledge of fungal genetics and plant/fungal interactions. P: Cons inst; Pl Path 300 & 332 recommended; Genetics 466 or equiv; general microbiol crse.

677 Advanced Topics in Medical Microbiology. I, II, SS; 1-3 cr (B-A). Lectures on a specialized topic of current interest in medical microbiology. Course content will vary with instructor. P: Grad st or cons inst.

681 Senior Honors Thesis. I, II, SS; 3 cr (A). Independent research topic (for students in the Honors program). P: Cons honors advisor.

682 Senior Honors Thesis. I, II, SS; 3 cr (A). Independent research topic. Continuation of MM&I 681. P: Cons honors advisor.

696 Critical Thinking in Medical Microbiology and Immunology. I; 3 cr (B-A). Students will present assigned research papers from journals for critical evaluation by the class. In addition, students will write critiques of each paper evaluating the paper's introduction, methods, results, and discussion sections. P: MM&I 301 & 341, or cons inst.

699 Directed Study. I, II, SS; 1-3 cr (A). P: Cons inst.

MEDICAL PHYSICS

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265 Introduction to Medical Physics. (Crosslisted with Physics) II; 2 cr (P-I). Primarily for premeds and other students in the medical and biological sciences. Applications of physics to medicine and medical instrumentation. Topics: biomechanics, sound and hearing, pressure and motion of fluids, heat and temperature, electricity and magnetism in the body, optics and the eye, biological effects of light, use of ionizing radiation in diagnosis and therapy, radiation safety, medical instrumentation. Two lectures with demonstrations per week. P: A yr crse of college level intro physics.

410 Radiobiology. (Crosslisted with H Oncol) Even yrs.; II; 2-3 cr (B-E). Effects of ionizing radiations of living cells and organisms, including physical, chemical, and physiological bases of radiation cytotoxicity, mutagenicity, and carcinogensis; lecture and lab.

463 Radioisotopes in Medicine and Biology. (Crosslisted with Physics) I; 2-3 cr (P-I). Physical principles of radioisotopes used in medicine and biology and operation of related equipment; lecture and lab. P: Intro physics.

471 Selected Topics in Medical Physics. I or II; 1-3 cr. Various subjects of interest to medical physics faculty and students. P: Cons inst.

501 Radiological Physics and Dosimetry. (Crosslisted with H Oncol, Physics, BME) I; 3 cr (A). Interactions and energy deposition by ionizing radiation in matter; concepts, quantities and units in radiological physics; principles and methods of radiation dosimetry. P: Calculus and modern physics.

506 Monte Carlo Radiation Transport. (Crosslisted with N E) Odd yrs.; II; 3 cr. Use of Monte Carlo technique for applications in nuclear engineering and medical physics. Major theory of Monte Carlo neutral particle transport is discussed. Standard Monte Carlo transport software is used for exercises and projects. Major emphasis is on analysis of real-world problems. P: NEEP 305 or equiv and one of NEEP 405, 408, Med Phys 501 or 569, or cons inst.

530 Medical Imaging Systems. (Crosslisted with BME) II; 3 cr. 2D Fourier image representation, sampling, and image filtering with applications in medical imaging. Principles of operation, impulse responses, signal-to-noise, resolution and design tradeoffs in projection radiography, tomography, nuclear medicine, ultrasound, and magnetic resonance imaging. P: ECE 330 or Med Phys 473 or equiv or cons inst. Knowledge of linear signals & systems, convolution, basic probability, Id Fourier Transforms.

559 Patient Safety and Error Reduction in Healthcare. (Crosslisted with ISyE) II; 2 cr (I). Techniques for evaluating and reducing risks in medical procedures, including probabilistic risk assessment methods, failure mode and effects analysis, human factors analysis, and quality management. Discussions of patient safety standards, recommendations from agencies, and continual quality improvement. P: Jr st or cons inst.

566 Physics of Radiotherapy. (Crosslisted with BME) II; 3 cr. Ionizing radiation use in radiation therapy to cause controlled biological effects in cancer patients. Physics of the interaction of the various radiation modalities with body-equivalent materials, and physical aspects of clinical applications; lecture and lab. P: Med Phys 501.

567 The Physics of Diagnostic Radiology. (Crosslisted with BME) I; 3 cr (B-I). Physics of x-ray diagnostic procedures and equipment, radiation safety, general imaging considerations; lecture and lab. P: Modern physics, calculus, and Fourier analysis, or cons inst.

568 Magnetic Resonance Imaging (MRI). (Crosslisted with BME) II; 3 cr. Physics and technology of magnetic resonance imaging (MRI), emphasizing techniques employed in medical diagnostic imaging. Major topics: physics of MR, pulse sequences, hardware, imaging techniques, artifacts, and spectroscopic localization. P: Crses in mod physics & calc, incl Fourier Anal, req. Crses in other med imaging tech e.g. Med Phys 567, & crses in signal processing, or Med Phys 573 recommended.

569 Health Physics. (Crosslisted with N E) II; 4 cr. Physical and biological aspects of the use of ionizing radiation in industrial and academic institutions; physical principles underlying shielding instrumentation, waste disposal; biological effects of low levels of ionizing radiation; lecture and lab. P: Cons inst.

570 Advanced Brachytherapy Physics. Odd yrs.; II; 3 cr. The use of radioactive sources for radiotherapy including: materials used, source construction dosimetry theory and practical application, dosimetric systems, localization and reconstruction. The course covers low dose rate, high dose rate and permanently placed applications. P: Med Phys 501& 566 or equiv.

571 Advanced External Radiation Oncology Physics. I; 3 cr. Physics of ionizing radiation therapy with emphasis on external beam dosimetry and treatment planning. P: Med Phys 501 & 566.

573 Medical Image Science: Deterministic Aspects. (Crosslisted with BME) I; 3 cr. The conceptual and mathematical foundations of linear systems theory in medical imaging, with example demonstrations of their applications in particular medical imaging modalities. P: 1 yr each of undergrad physics & calc or cons inst.

574 Medical Image Science: Stochastic Aspects. (Crosslisted with BME) II; 3 cr. The conceptual and mathematical foundations of probability and statistics in medical imaging, and demonstrations of the applications of these foundations in particular medical imaging modalities. P: Med Phs/BME 573 or cons inst.

575 Diagnostic Ultrasound Physics. (Crosslisted with BME) I; 3 cr. Propagation of ultrasonic waves in biological tissues; principles of ultrasonic measuring and imaging instrumentation; design and use of currently available tools for performance evaluation of diagnostic instrumentation; biological effects of ultrasound. P: Modern physics, calculus & Fourier analysis or cons inst.

619 Microscopy of Life. (Crosslisted with Physics, Anatomy, BME, Chem, Phmcol-M, Radiol) II; 3 cr (I). Survey of state of the art microscopic, cellular and molecular imaging techniques, beginning with subcellular microscopy and finishing with whole animal imaging. P: 2nd semester intro physics including light & optics (e.g. 104, 202, 208) or cons inst.

661 Rad Lab—Radiotherapy Physics. I; 2 cr. P: Med Phys 566.

662 Rad Lab—Diagnostic Radiological Physics. I or II or SS; 1 cr. P: Med Phys 567.

663 Rad Lab—Nuclear Medicine Physics. II; 1 cr. P: Med Phys 463.

664 Rad Lab—Health Physics. I or II or SS; 1 cr. P: Grad st.

665 Rad Lab—CT, MRI, and DSA Physics. I or II or SS; 1 cr. P: Med Phys 567 or cons inst.

666 Rad Lab—Medical Ultrasound Physics. I, II; 1 cr. P: Grad st.

679 Radiation Physics Metrology. II; 3 cr. Metrology, the science of measurement, is a critical component of medical physics. Topics covered: measurement statistics, determination of uncertainty, characteristics of ionization chambers, electrometers and other ionizing radiation measurement devices. Effects of instrumentation on clinical measurements. P: Med Phys 501; Med Phys 566 & 567 recommended.

699 Independent Reading or Research. I, II, SS; 1-3 cr (A).

MEDICINE

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448 A Team Approach to Emergency Care. (Crosslisted with Phy Asst, Nursing, Phm Prac) II; 3-4 cr. Concepts and skills related to the provision of advanced emergency medical care, in primary and secondary settings, by a health care team. P: PA classification or cons inst.

523 Clinical Exercise Testing & Training. (Crosslisted with Kines, Nursing) I or II or SS; 3 cr. Physiological basis and methods of human exercise testing and training. Topics: clinical exercise physiology, exercise testing protocols, cardiopulmonary monitoring, basic ECG interpretation, exercise prescription. P: Kines 314 or cons inst.

625 Toxicology I. (Crosslisted with M&Envtox, Oncology, Path, Phmcol-M, Pop Hlth, Ahabs, Phm Sci) I; 3 cr (B-A). Basic principles of toxicology and biochemical mechanisms of toxicity in mammalian species and man. Correlation between morphological and functional changes caused by toxicants in different organs of the body. P: Biochem 501 & Physiol 335 or cons inst. Path 401 & Phmcol 401 or equiv recommended.

626 Toxicology II. (Crosslisted with M&Envtox, Path, Phmcol-M, Pop Hlth, Ahabs, Phm Sci) II; 3 cr (B-A). A course surveying the basic methods and fundamental biochemical mechanisms of toxicity. Toxicity in mammalian organ systems, techniques for evaluating toxicity, as well as mechanisms of species specificity, and environmental interactions (with toxicant examples) are presented. P: Env Tox 625 or cons inst.

699 Independent Study. 0-9 cr (A).

NEUROSCIENCE TRAINING PROGRAM

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500 Undergraduate Neurobiology Seminar. I, II; 1 cr (B-I). Neurobiology seminar for undergraduates who are taking the neurobiology option within the biology major. P: An intro biol crse (Bot/Zool 151/152; or Biocore 301/303; or equiv).

523 Neurobiology. (Crosslisted with Zoology, Psych) I; 3 cr (B-I). Basic mechanisms in cellular neurophysiology: electrophysiology and chemistry of nerve signals, mechanisms in integration, simple nervous pathways and their behavioral correlates. P: Biocore 323 or Zool 151/152 or Zool 101 plus an additional zool crse & a yr each of chem & physics.

524 Neurobiology II: An Introduction to the Brain and Behavior. (Crosslisted with Psych, Zoology, Physiol) II; 3 cr (B-I). An introduction to studies of the human nervous system covering neuroanatomy of the brain, neuronal coding, sensory and motor systems, biological rhythms, arousal, attention, physiological regulation, reward, aversion, learning and memory. P: Zool 523, equiv crse in physiol, or cons inst.

610 Cellular and Molecular Neuroscience. (Crosslisted with Physiol, Phmcol-M) I; 4 cr (B-I). Study of original papers leading to an understanding of the molecular basis of electrical activity in neurons. Topics include voltage-sensitive currents, molecular biology of neuronal receptors, synaptic transmission and sensory transduction. Lectures supplemented with experimental demonstrations and discussion sessions. P: Zoo 523 or equiv.

611 Systems Neuroscience. (Crosslisted with Anatomy, Phmcol-M, Physiol, Psych) II; 4 cr (A). Introduction to the anatomy and physiology of the mammalian nervous system. Lectures will cover the neuroanatomy of the major subdivisions of the human brain, the major sensory and motor systems, and higher order functions. Lab/discussion sections will emphasize readings from the primary literature and hands-on dissections. P: Physiol 610.

619 Biology of Mind. (Crosslisted with Zoology, Anthro, Psych) I; 3 cr (B-D). Origins and structures of mind, brain, and consciousness. Transitions from early mammalian through primate to hominid intelligence. Genetics and plasticity in brain development. Modern studies of human brain mechanisms and consciousness. P: Jr st; college level elem crse in biology or psych.

625 Brain Cell Cultures: A Laboratory Course. (Crosslisted with Physiol) Alt yrs.; II; 2 cr (D). Basic skills to culture cells from the central nervous system (cortical neurons, astrocytes and oligodendrocytes). Basic skills to characterize different cultures. P: Intro crses in biochem, cell biology & anatomy.

629 Molecular and Cellular Mechanisms of Memory. (Crosslisted with Physiol) Alt yrs.; I; 3 cr (B-A). Course will focus on the cell signaling and the resulting structural changes that occur at neuronal synapses during memory formation. The aim is to understand how the synaptic changes underlying memory occur. P: Crse in cellular neurosci (Neurosci 523 or equiv); Biochem 501 or equiv.

630 Neuronal Mechanisms for Sensation and Memory in Cerebral Cortex. (Crosslisted with Anatomy, Physiol) Alt yrs.; II; 3 cr (B-D). Current literature will be considered in lectures and discussions that provides insight into how the cerebral cortex processes sensory information to generate and store cogent representations of the external world. The course includes laboratory exercises and demonstrations. P: Intro neurosci crse highly recommended: Neurosci/Anat/Phmcol/Physiol 611, Med Sc-M 731, Comp Bio 505, Zool/Neurosci/Psych 523, Psych/Neurophy/Neurosci/Zool 524; or cons inst.

635 Neurobiology of Disease. (Crosslisted with Zoology) Alt yrs.; I; 2 cr (B-A). Seminar course relating major categories of human neurological and ophthalmological disease to fundamental topics in neurobiology. P: Zool/Neurosci 523 & 524 or cons inst.

675 Special Topics. I, II, SS; 1-3 cr (A). P: Variable.

681 Senior Honors Thesis. I, II, SS; 3 cr (A). Research and thesis in neuroscience. P: Cons inst.

682 Senior Honors Thesis. I, II, SS; 3 cr (A). Continuation of 681. P: Neurosci 681, cons inst.

691 Undergraduate Thesis. I, II, SS; 3-6 cr (A). Research and thesis in neuroscience. P: Cons inst.

692 Undergraduate Thesis. I, II, SS; 3-6 cr (A). Continuation of 691. P: Cons inst.

699 Directed Study in Research. I, II, SS; 1-6 cr (A). Directed research in neuroscience. P: Cons inst.

ONCOLOGY

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401 Introduction to Experimental Oncology. I; 2 cr (B-I). Biological processes associated with and characteristic of neoplasia. P: Biol & org chem or cons inst.

545 Topics in Biotechnology. (Crosslisted with Microbio) II; 1 cr (I). Seminars on current topics in agricultural, medical, and industrial biotechnology such as: microbiological production of food, drink, biopharmaceuticals; production methods, genetic engineering (vectors, recombination cloning), continuous fermentation; bioconversion processes and production of chemicals from biomass; plant biotechnology; transgenic animals. P: Biochem 501 and Genetics 466 or equiv.

625 Toxicology I. (Crosslisted with M&Envtox, Medicine, Path, Phmcol-M, Pop Hlth, Ahabs, Phm Sci) I; 3 cr (B-A). Basic principles of toxicology and biochemical mechanisms of toxicity in mammalian species and man. Correlation between morphological and functional changes caused by toxicants in different organs of the body. P: Biochem 501 & Physiol 335 or cons inst. Path 401 & Phmcol 401 or equiv recommended.

640 General Virology—Multiplication of Viruses. (Crosslisted with Microbio, Pl Path) I; 3 cr (B-D). Bacterial and animal viruses, their structure, multiplication, and genetics. P: Intro crses in bact, biochem & genetics.

675 Advanced or Special Topics in Cancer Research. I, II; 1-3 cr (B-I). P: Cons inst.

699 Special Research Problems. I, II, SS; 1-3 cr (A). P: Cons inst.

PATHOLOGY AND LABORATORY MEDICINE

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210 HIV: Sex, Society and Science. I; 3 cr (B-E). HIV kills three million people per year, more than any other infectious disease. We will learn about the transmission, immunology, virology, vaccinology and societal impact of this virus. Six of the world's leading HIV scientists will give guest lectures. P: HS biol crse. Open to all Undergrads.

299 Independent Study. I, II, SS; 1-3 cr. P: Cons inst. Open to Fr.

399 Independent Study. I, II, SS; 1-4 cr. P: So st & cons inst.

404 Pathophysiologic Principles of Human Diseases. II; 3-4 cr (B-A). Primarily for students of pharmacy and nursing to provide a basic understanding of the causes, pathophysiology, pathology and clinical manifestations of disease states. Required course for pharmacy and nursing programs. P: Physiol 335.

625 Toxicology I. (Crosslisted with M&Envtox, Medicine, Oncology, Phmcol-M, Pop Hlth, Ahabs, Phm Sci) I; 3 cr (B-A). Basic principles of toxicology and biochemical mechanisms of toxicity in mammalian species and man. Correlation between morphological and functional changes caused by toxicants in different organs of the body. P: Biochem 501 & Physiol 335 or cons inst. Path 401 & Phmcol 401 or equiv recommended.

626 Toxicology II. (Crosslisted with M&Envtox, Medicine, Phmcol-M, Pop Hlth, Ahabs, Phm Sci) II; 3 cr (B-A). A course surveying the basic methods and fundamental biochemical mechanisms of toxicity. Toxicity in mammalian organ systems, techniques for evaluating toxicity, as well as mechanisms of species specificity, and environmental interactions (with toxicant examples) are presented. P: Env Tox 625 or cons inst.

651 Quality Assurance Basics. I, II, SS; 1 cr. Describes the regulatory requirements that all healthcare laboratories must follow to assure quality throughout the testing process. Covers the extensive Clia'88 regulations and professional accreditation (Jcaho, CAP and Cola) standards. P: Path 657 & Sr st in clin lab sci, or bachelor's degree in clin lab sci, or ASCP or NCA cert in clin lab sci, or admission to the Graduate Certificate in Laboratory Quality Management.

652 Quality Assurance Projects. I, II, SS; 2 cr. Provides a laboratory application for ensuring quality results through quality assurance practices in healthcare laboratories. This includes evaluating current quality assurance policies and practices and developing new policies to meet the many mandated Clia'88 regulatory requirements and professional accreditation standards. P: Sr st in clin lab sci, or bachelor's degree in clin lab sci, or ASCP or NCA cert in clin lab sci, or admission to the Graduate Certificate in Laboratory Quality Management.

653 Method Validation Basics. I, II, SS; 1 cr. Describes the fundamental experimental and statistical techniques used to validate the performance of analytical methods, including experiments for working range, replication, interference, recovery, and comparison of methods and associated data calculations, such as t-test and linear regression statistics. P: Sr st in clin lab sci, or bachelor's degree in clin lab sci, or ASCP or NCA cert in clin lab sci, or admission to the Graduate Certificate in Laboratory Quality Management.

654 Method Validation Projects. I, II, SS; 2 cr. Provides a laboratory application of the principles and techniques of method validation studies, including experiments for working range, replication, interference, recovery, and comparison of methods and associated data calculations, such as t-test and linear regression statistics. P: Path 653 & Sr st in clin lab sci, or bachelor's degree in clin lab sci, or ASCP or NCA cert in clin lab sci, or admission to the Graduate Certificate in Laboratory Quality Management.

655 Quality Control Basics. I, II, SS; 1 cr. Describes the fundamental principles, terminology, and practices of statistical quality control as applied with analytical testing processes in healthcare laboratories. Covers the plotting of Levey-Jennings control chart and interpretation of control data using the Westgard multirule procedure. P: Sr st in clin lab sci, or bachelor's degree in clin lab sci, or ASCP or NCA cert in clin lab sci, or admission to the Graduate Certificate in Laboratory Quality Management.

656 Quality Control Projects. I, II, SS; 2 cr. Provides a laboratory application of the principles and techniques of statistical quality control in a real-world setting. Involves auditing QC data in an analytical laboratory and critical review of laboratory QC applications. P: Path 655 & Sr st in clin lab sci, or bachelor's degree in clin lab sci, or ASCP or NCA cert in clin lab sci, or admission to the Graduate Certificate in Laboratory Quality Management.

657 Quality Planning Basics. I, II, SS; 1 cr. Describes the principles and approach for setting method performance specifications and selecting statistical QC procedures on the basis of the quality required for a laboratory test. Introduces the chart of operating specifications as a practical quality-planning tool. P: Sr st in clin lab sci, or bachelor's degree in clin lab sci, or ASCP or NCA cert in clin lab sci, or admission to the Graduate Certificate in Laboratory Quality Management.

658 Quality Planning Projects. I, II, SS; 2 cr. Provides a laboratory application of the principles, theory, and approach for establishing method performance specifications and selecting statistical QC procedures for laboratory methods. Involves specific tests and methods in an analytical service laboratory. P: Path 657 & Sr st in clin lab sci, or bachelor's degree in clin lab sci, or ASCP or NCA cert in clin lab sci, or admission to the Graduate Certificate in Laboratory Quality Management.

691 Senior Thesis. I, II, SS; 3 cr (A). Independent research in the areas of structural virology, molecular virology, viral pathogenesis, or immunity to virus infection. A seminar presentation of research data and a written thesis are required in the final semester. P: Jr or Sr st & cons inst.

692 Senior Thesis. I, II, SS; 1-3 cr. Independent research in the area of cellular and molecular pathology. A written thesis is required in the final semester. P: Jr or Sr st & cons inst.

699 Independent Study. I, II, SS; 1-4 cr (A). P: Jr st & cons inst.

PHARMACOLOGY

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610 Cellular and Molecular Neuroscience. (Crosslisted with Physiol, Neurosci) I; 4 cr (B-I). Study of original papers leading to an understanding of the molecular basis of electrical activity in neurons. Topics include voltage-sensitive currents, molecular biology of neuronal receptors, synaptic transmission and sensory transduction. Lectures supplemented with experimental demonstrations and discussion sessions. P: Zoo 523 or equiv.

611 Systems Neuroscience. (Crosslisted with Anatomy, Neurosci, Physiol, Psych) II; 4 cr (A). Introduction to the anatomy and physiology of the mammalian nervous system. Lectures will cover the neuroanatomy of the major subdivisions of the human brain, the major sensory and motor systems, and higher order functions. Lab/discussion sections will emphasize readings from the primary literature and hands-on dissections. P: Physiol 610.

619 Microscopy of Life. (Crosslisted with Physics, Anatomy, BME, Chem, Med Phys, Radiol) II; 3 cr (I). Survey of state of the art microscopic, cellular and molecular imaging techniques, beginning with subcellular microscopy and finishing with whole animal imaging. P: 2nd semester intro physics including light & optics (e.g. 104, 202, 208) or cons inst.

620 Eukaryotic Molecular Biology. (Crosslisted with Biochem) II; 2 cr (I). This course focuses on the basic molecular mechanisms that regulate DNA, RNA, and protein metabolism in eukaryotic organisms. This course is intended for advanced undergraduates and first year graduate students with a firm knowledge of basic biochemistry. P: Biochem 508 or equiv.

625 Toxicology I. (Crosslisted with M&Envtox, Medicine, Oncology, Path, Pop Hlth, Ahabs, Phm Sci) I; 3 cr (B-A). Basic principles of toxicology and biochemical mechanisms of toxicity in mammalian species and man. Correlation between morphological and functional changes caused by toxicants in different organs of the body. P: Biochem 501 & Physiol 335 or cons inst. Path 401 & Phmcol 401 or equiv recommended.

626 Toxicology II. (Crosslisted with M&Envtox, Medicine, Path, Pop Hlth, Ahabs, Phm Sci) II; 3 cr (B-A). A course surveying the basic methods and fundamental biochemical mechanisms of toxicity. Toxicity in mammalian organ systems, techniques for evaluating toxicity, as well as mechanisms of species specificity, and environmental interactions (with toxicant examples) are presented. P: Env Tox 625 or cons inst.

630 Cellular Signal Transduction Mechanisms. (Crosslisted with Zoology, Biochem) I; 3 cr (B-D). Lecture-discussion. Comprehensive coverage of human hormones, growth factors and other mediators; emphasis on hormone action and biosynthesis, cell biology of hormone-producing cells. P: Intro biochem (Biochem 501 or 507 & 508) & cell biology (Biocore 303 or Zool 570 or Path 750) or cons inst.

699 Independent Study. I, II, SS; 1-3 cr (A). P: Cons inst.

PHYSIOLOGY

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335 Physiology. I, II, SS; 5 cr (B-I). Lectures, recitations, demonstrations, and labs. P: Biol or zool & gen chem before enroll. Not open to Fr.

524 Neurobiology II: An Introduction to the Brain and Behavior. (Crosslisted with Neurosci, Psych, Zoology) II; 3 cr (B-I). An introduction to studies of the human nervous system covering neuroanatomy of the brain, neuronal coding, sensory and motor systems, biological rhythms, arousal, attention, physiological regulation, reward, aversion, learning and memory. P: Zool 523, equiv crse in physiol, or cons inst.

533 Molecular Physiology. II; 2 cr (I). This course will introduce functional aspects of mammalian organ systems from a molecular perspective. Human diseases will receive a special emphasis, and diseases will be used to illustrate the connection between molecules and biological function. P: Chem 103 & 104 or 109 or 115 & 116; Physics 201 & 202 or 207 & 208; Zoology 151 & 152 or Biocore 303 & 304; Math 221 & 222 or 275 & 276. Recommended but not required: Biocore 323, biochem (e.g. Biochem 507 & 508), cell biology (e.g. Zoology 570).

610 Cellular and Molecular Neuroscience. (Crosslisted with Neurosci, Phmcol-M) I; 4 cr (B-I). Study of original papers leading to an understanding of the molecular basis of electrical activity in neurons. Topics include voltage-sensitive currents, molecular biology of neuronal receptors, synaptic transmission and sensory transduction. Lectures supplemented with experimental demonstrations and discussion sessions. P: Zoo 523 or equiv.

611 Systems Neuroscience. (Crosslisted with Anatomy, Neurosci, Phmcol-M, Psych) II; 4 cr (A). Introduction to the anatomy and physiology of the mammalian nervous system. Lectures will cover the neuroanatomy of the major subdivisions of the human brain, the major sensory and motor systems, and higher order functions. Lab/discussion sections will emphasize readings from the primary literature and hands-on dissections. P: Physiol 610.

625 Brain Cell Cultures: A Laboratory Course. (Crosslisted with Neurosci) Alt yrs.; II; 2 cr (D). Basic skills to culture cells from the central nervous system (cortical neurons, astrocytes and oligodendrocytes). Basic skills to characterize different cultures. P: Intro crses in biochem, cell biology & anatomy.

629 Molecular and Cellular Mechanisms of Memory. (Crosslisted with Neurosci) Alt yrs.; I; 3 cr (B-A). Course will focus on the cell signaling and the resulting structural changes that occur at neuronal synapses during memory formation. The aim is to understand how the synaptic changes underlying memory occur. P: Crse in cellular neurosci (Neurosci 523 or equiv); Biochem 501 or equiv.

630 Neuronal Mechanisms for Sensation and Memory in Cerebral Cortex. (Crosslisted with Neurosci, Anatomy) Alt yrs.; II; 3 cr (B-D). Current literature will be considered in lectures and discussions that provides insight into how the cerebral cortex processes sensory information to generate and store cogent representations of the external world. The course includes laboratory exercises and demonstrations. P: Intro neurosci crse highly recommended: Neurosci/Anat/Phmcol/Physiol 611, Med Sc-M 731, Comp Bio 505, Zool/Neurosci/Psych 523, Psych/Neurophy/Neurosci/Zool 524; or cons inst.

675 Selected Topics in Physiology. I, II, SS; 1-3 cr (B-A). Each topic taught once every two years: advanced cardiovascular physiology, advanced respiratory physiology, advanced endocrinology, membrane transport physiology and neurobiology. P: Cons inst.

699 Independent Work. 1-4 cr (A).

POPULATION HEALTH SCIENCES

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155 Introduction to the Biology of Aging. I; 2 cr (I-E). P: One sem of gen biology at college level.

308 People, Chemicals, Environment. (Crosslisted with Envir St, M&Envtox) II; 2 cr (B-I). An interdisciplinary approach to problems related to the presence of biologically active substances and potentially hazardous synthetic chemicals in man's environment. Principles of toxicology, drugs and drug abuse, pesticide chemicals, radiation hazards, industrial chemicals, food poisoning, and problems related to exposure to foreign compounds such as carcinogenesis, mutagenesis, and teratogenesis. P: A crse in biology & one crse in chem or cons inst.

375 Concepts and Methods in Population Health Sciences. II; 1 cr (S-I). Introduces concepts and methods of epidemiology, health services research, health policy and financing, disease prevention, and public health. Intended as an overview for undergraduates of all disciplines and who might consider graduate work in population health sciences. P: Jr st or cons inst.

380 Contemporary Population Problems for Honors. (Crosslisted with Soc, Rur Soc) I or II; 3 cr (Z-I). This course is designed to identify, examine the nature and evaluate the evidence regarding key population problems affecting modern societies in the developed and developing world. The course emphasizes the development of demographic models as a tool to frame, define and investigate these problems. Examples of problems studied include: relations between population growth and environment, population growth and socioeconomic development, population and emergence of new diseases. P: Crse in coll level math; crse in coll level biology; or cons inst. Open to Fr.

471 Introduction to Environmental Health. (Crosslisted with Envir St) I; 3 cr (B-I). Impact of environmental problems on human health; biological hazards to human health from air and water pollution; radiation; pesticides; noise; problems related to food, occupation and environment of the work place; accidents. Physical and chemical factors involved. P: A course in biology; Jr st.

502 Air Pollution and Human Health. (Crosslisted with Envir St) I; 3 cr (B-D). Toxicologic, controlled and epidemiologic studies on major air pollutants. Overview of study methods, lung physiology and pathology; air pollution sources, types, meteorology, sampling methods, controls and regulations. P: Jr st, a course in biology.

548 The Economics of Health Care. (Crosslisted with Econ, Pub Affr) I or II; 3-4 cr (S-I). Analysis of the health care industry. Markets for hospitals and physicians' care, markets for health manpower, and the role of health insurance. P: Econ 301, or Pub Affr 880 or cons inst.

553 International Health and Global Society. (Crosslisted with Med Hist, Hist Sci) I; 3 cr (Z-I). Major problems in international health from 1750 to the present. Focus on disease epidemiology and ecology; political economy of health; migration; quarantine; race, ethnicity, and health care; international health research; cross-cultural healing; mental and maternal health; growth of international health organizations. P: Jr or Sr st, or cons inst.

575 The Biological Processes of Aging. (Crosslisted with Anatomy) II; 3 cr (B-I). Lecture. Theories and mechanisms of the aging process with special reference to biological changes within and between cultures. Studies of decreasing ability to adapt to environment with age, due to anatomical and physiological changes in the human body, organ systems, cellular and molecular levels. P: Jr st, 2 sems of chem, gen biol or zool, intro physiol or cons inst.

603 Clinical and Public Health Microbiology. (Crosslisted with MM&I) II; 5 cr (I). Lecture-seminar sessions. Lectures (44) describe microorganisms of clinical and public health significance. Seminar sessions (14) discuss issues and controversies of specimen receiving and processing, bacteremia, serodiagnosis of infectious agents, antimicrobial susceptibility testing, laboratory management, and novel approaches to detect infectious agents. P: MM&I 301 & 302 or equiv.

621 Introduction to Nutritional Epidemiology. (Crosslisted with Nutr Sci) I; 1 cr (A). Techniques used to evaluate relationships of diet to health and disease in human populations; integration of knowledge gained with results of animal and clinical studies toward understanding dietary risk or protective factors for disease. Includes advanced diet assessment and basic epidemiologic approaches. P: Stat 301 or equiv & Nutr Sci 332 or cons inst.

625 Toxicology I. (Crosslisted with M&Envtox, Medicine, Oncology, Path, Phmcol-M, Ahabs, Phm Sci) I; 3 cr (B-A). Basic principles of toxicology and biochemical mechanisms of toxicity in mammalian species and man. Correlation between morphological and functional changes caused by toxicants in different organs of the body. P: Biochem 501 & Physiol 335 or cons inst. Path 401 & Phmcol 401 or equiv recommended.

626 Toxicology II. (Crosslisted with M&Envtox, Medicine, Path, Phmcol-M, Ahabs, Phm Sci) II; 3 cr (B-A). A course surveying the basic methods and fundamental biochemical mechanisms of toxicity. Toxicity in mammalian organ systems, techniques for evaluating toxicity, as well as mechanisms of species specificity, and environmental interactions (with toxicant examples) are presented. P: Env Tox 625 or cons inst.

635 Cross-National Health Services Systems and Public Policy. (Crosslisted with Soc, Soc Work) Irr.; 3 cr (S-A). General concept of a health services system and how it interacts with larger society. Major references to U.S., Sweden and Great Britain; additional data from several other countries. Implications for public policy. P: Jr st and an intro crse in soc or cons inst.

638 Growth in Need and Demand for Health Services. (Crosslisted with Soc, Pub Affr, Soc Work) Irr.; 3 cr (S-A). Examine factors that greatly increased the use of health services and disproportionately increased expenditures for them in the U.S. and other industrialized countries, policy implications. P: Jr st or cons inst.

650 Special Topics. 1-3 cr. Variable content course. Refer to Timetable or contact department for specific list of course sections, titles, prerequisites, and instructors. P: Grad stdt in population health or cons inst.

699 Independent Reading. 1-5 cr (A). To gain additional information on specific research problems or advanced training in the areas covered by Prev Med staff. P: Grad st or cons inst.

RADIOLOGY

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619 Microscopy of Life. (Crosslisted with Physics, Anatomy, BME, Chem, Med Phys, Phmcol-M) II; 3 cr (I). Survey of state of the art microscopic, cellular and molecular imaging techniques, beginning with subcellular microscopy and finishing with whole animal imaging. P: 2nd semester intro physics including light & optics (e.g. 104, 202, 208) or cons inst.