Thursday, September 29, 2005

8:30-8:55

Continental Breakfast – Upstairs Foyer (2nd floor)
Registration is Necessary

9:00

Introductions

Dr. Patricia J. Keely – Chair, Symposium Committee
Assistant Professor, Department of Pharmacology

Session Chair: Dr. Richard A. Anderson

9:15-9:35

PIASy is a SUMO Ligase for NEMO Critical for NF-kB Activation by Genotoxic Stress
Angela M. Mabb
Dr. Shigeki Miyamoto
Molecular and Cellular Pharmacology Program

9:40-10:00

Dominant Negative PKC-e Inhibits Ventricular Myocytes
Responses to Endothelin-1
Misuk Kang
Dr. Jeffery W. Walker
Molecular and Cellular Pharmacology Program

10:05-10:25

Selection and Characterization of Ligand Regulated Peptide Aptamers that Inhibit the 5'AMP-Activated Protein Kinase
Russell Miller
Dr. Peter J. Belshaw
Biochemistry Department

10:30-10:50

6-Hydroxydopamine Activates the Antioxidant Response Element Through a Combination of Oxidative, Excitotoxic, and Potential Structural Factors
Rebekah Jakel
Dr. Jeffrey A. Johnson
Neuroscience Training Program, MSTP Program

11:00–12:00

Poster Session and Coffee Break – Main Lobby

12:00-1:00

Keynote Address:
Dynamics in Drug Design: Fluctuations in Target Structure and Freeze-Frame Inhibitors in the Cholinergic Nervous System

Dr. Palmer W. Taylor
Founding Dean, School of Pharmacy &
Pharmaceutical Sciences
University of California, San Diego

1:00-2:00

Lunch – Main Floor Dining Room

Session Chair: Dr. Cynthia M. Czajkowski

2:00-2:20

Disruption of b2 K102-T110, a Region that Links the GABA-A Receptor’s Agonist Binding Site to the Inner b-sheet Domain, Impairs Channel Activation
Srinivasan P Venkatachalan
Dr. Cynthia Czjakowski
Physiology Department

2:25-2:45

Regulation of Adhesion Dynamics by the Adaptor Protein, RACK1
Ashley Doan
Dr. Anna Huttenlocher
Molecular and Cellular Pharmacology

2:50-3:10

Ligand-Induced Conformational Transitions in the GABAA Receptor Probed with Site-Specific Fluorescent Labels
Yukiko Muroi
Meyer Jackson
Molecular and Cellular Pharmacology Program

3:15-3:35

Nuclear Phosphatidylinositol 4,5-Bisphosphate and Pre-mRNA Splicing
Michael L. Gonzales
Richard A. Anderson
Molecular and Cellular Pharmacology Program

4:00–5:00

Poster Session and Reception – Main Lobby