4th Annual
Signal Transduction Symposium


University of Wisconsin – Madison
Fluno Center Executive Education
601 University Avenue/1-877-77-FLUNO



Tuesday, November 30, 2004

8:30-8:55

Continental Breakfast
– Upstairs Foyer (2nd floor)
Registration is Necessary

9:00

Dr. Patricia J. Keely
- Chair, Symposium Committee
Assistant Professor, Department of Pharmacology

Dr. George Wilding
- Welcome
Director - Comprehensive Cancer Center

Dr. Richard A. Anderson
- Introduction
Director, Molecular and Cellular Pharmacology Program

Session Chair: Dr. Arnold Ruoho, S. Jonathan Singer Professor
Chair – Department of Pharmacology


9:15-9:35

The Syndecan-1 Ectodomain Regulates avb3 Integrin Activity in Human Mammary Carcinoma Cells
Deanna Lee M. Beauvais
Dr. Alan C. Rapraeger
Molecular and Cellular PharmacologyProgram

9:40-10:00

p190RhoGAP regulates breast epithelial tubulogenesis in
3D Collagen Matrices
Michele Wozniak
Dr. Patricia Keely
Cellular and Molecular Biology

10:05-10:25

Predicting Murine Mammary Epithelial Cell Population Demographics using a Mathematical Model of Stem Cell Regulation
Amy Paguirigan
Dr. David J. Beebe
Dept. of Biomedical Engineering

10:30-10:50

Actions of the Functional Upstream Domain of Protein F1 of Streptococcus pyogenes on the Conformation of Fibronectin
Martin George Ensenberger
Dr. Deane F. Mosher
Molecular and Cellular Pharmacology Program

11:00-12:00

Poster Session and Coffee Break


12:00-1:00

Keynote Address:
“The Architectural Basis of Signaling for Tissue Specificity in Normal and Malignant Breast”

Dr. Mina Bissell
Distinguished Scientist, Life Sciences Division Lawrence Berkeley National Laboratory

1:00-2:00

Lunch – Main Floor Dining Room


Session Chair: Dr. Emery Bresnick, Professor of Pharmacology

2:00-2:20

Calpain-mediated proteolysis of talin regulates adhesion
dynamics
Santos J. Franco
Dr. Anna Huttenlocher
Cellular and Molecular Biology Program

2:25-2:45

An activator Protein-1-Notch-4 angiogenic vascular
remodeling pathway
Jing Wu
Dr. Emery H. Bresnick
Molecular and Cellular Pharmacology

2:50-3:10

The role of synaptotagmins in membrane fusion: a family of
metal sensors
Akhil Bhalla
Dr. Edwin Chapman
Molecular and Cellular Pharmacology Program

3:15-3:35

ATM activation lies downstream of ATR in response to
inhibition of DNA replication
Gerry Dodson
Dr. Randal Tibbetts
Cellular and Molecular Biology Program

4:00–5:00

Poster Session and Reception – Main Lobby



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