January 14

Jean-Pierre Changeux, Professor, College de France and the Institut Pasteur, Paris, France *
The Nicotinic Receptor at the Amino Acid Level: A Model of Allosteric Membrane Proteins
(More Info Here)

Student Host: J. Holden

January 21

William Bement, Associate Professor, Department of Zoology,
University of Wisconsin-Madison,
How are Transient Contractile Arrays Assembled? Lessons from Single Cell Wound Healing

Host: R. Anderson

January 28

Paul Harari, Associate Professor, Department of Human Oncology,
University of Wisconsin-Madison
Molecular Modulation of ErbB Family Signaling Pathways in Cancer Therapeutics

Host: S. Miyamoto

February 4

Hector DeLuca , Professor and Chair, Department of Biochemistry,
University of Wisconsin-Madison
2-Carbon-Modified Analogs of 1_,25-Dihydroxyvitamin D3 and Their Therapeutic Potential

Host: R. Anderson

February 11

To Be Announced

February 18

To Be Announced

February 25

Harinder Singh, Professor, Department of Molecular Genetics and Cell Biology,
University of Chicago, Associate Investigator, Howard Hughes Medical Institute**
Transcriptional Regulation of Cell Fates and Gene Expression in the Immune System

Host: E.H. Bresnick

March 4

Shigemi Matsuyama, Assistant Professor, Cell Biology, Blood Research Institute,
Department of Biochemistry, Medical College of Wisconsin
Bax-mediated Cell Death Signal and Ku70

Host: S. Miyamoto

March 11

Michael Schaller, Associate Professor, Department of Cell and Developmental Biology, University of North Carolina
Structural Insight into the Regulation of Focal Adhesion Kinase Signaling

Host: P. Keely

March 18

Spring Break

March 25

Robert Kingston, Professor of Genetics, Harvard Medical School * and **
Towards Establishing a Biochemical System to Understand Maintenance of Body Pattern

Student Host: H. Im

April 1

Marc Therrien, Director, Laboratory of Intracellular Signalling, Institut de Recherches Cliniques de Montreal, Department of Medicine, University of Montreal
Molecular Dissection of the RAS/MAP Kinase Pathway using Drosophila

Host: D. Wassarman

April 8

Kyunghee Choi, Assistant Professor, Department of Pathology and Immunology,
Washington University School of Medicine *
From Embryonic Stem (ES) Cells to Hematopoietic and Endothelial Cells

Student Host: H. Im

April 15

Kenneth Yamada, M.D., Ph.D., Branch Chief, Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, NIH *
Integrin Functions in Cell-Matrix Interactions, Signaling, and Development

Student Host: R. Doughman

April 22

Channing J. Der, Professor, Lineberger Comprehensive Cancer Center,
University of North Carolina – Chapel Hill *
Ras and Rho GTPases, Signaling, and Oncogenesis

Student Host: R. Doughman

April 29

Mark H. Ginsberg, M.D., Professor, Department of Cell Biology and Vascular Biology,
Scripps Research Institute
The Insider’s Approach to Cell Migration

Host: A. Huttenlocher

May 6

Danny Reinberg, Professor, Department of Biochemistry, Howard Hughes Medical Institute/University of Medicine and Dentistry of New Jersey,
Robert Wood Johnson Medical School *
Chromatin and Its Impact on Gene Expression and Cellular Memory

Host: C. Kiekhaefer
Student Host: H. Im

May 13

Nancy A. Speck , Professor, Department of Biochemistry, Dartmouth Medical School *
Runx1-CBFß and its Role in Hematopoietic Stem Cell Development

Student Host: J. Chu

May 20

Richard Neubig, M.D., Ph.D., Professor, Department of Pharmacology,
University of Michigan
Regulators of G Protein Signaling (RGS Proteins): Biological Function and Therapeutic

Potential Host: A. Ruoho

May 27

Michael Yaffe, M.D., Ph.D., Professor, Center for Cancer Research,
Massachusetts Institute of Technology
Proteomic Approaches to Cell Signaling by Serine/Threonine Kinases and Modular Binding Domains

Host: R. Anderson

MCP Career Opportunties Series
For those students considering careers in the Pharmaceutical Industry
and/or Biotechnology Industry

June 4

Dr. Ray Ruddon, CSO of Johnson and Johnson,
previous Director of Epply Cancer Research Institute,
previous Chair of Pharmacology at U. Michigan Medical School, and
previous Lab Chief at the National Cancer Institute.
Role of Genomics and Proteomics in Drug Development and Impact on the Practice of Medicine

Dr. Ruddon, Pharmacologist, will be the first of a series of ph.d's to give a general overview of their experiences in the Biotechnology Industry and/or discuss their scientific research.

Contact for information: Brandon Burbach, bburbach@students.wisc.edu, 262-5982.

Note to Graduate Students: Graduate Students are invited to attend a luncheon with Dr. Ruddon following the seminar in the Pharmacology Conference Room, 3765 MSC. There will
be an informal luncheon discussion on "Opportunities in Industry".

Dr. E. Bresnick

Sponsored by the Molecular and Cellular Pharmacology Graduate Program
Sponsored by the Molecular Biosciences Training Program

June 17,

12:15 - 1:15 pm

Dr. Elizabeth Goodwin has provided the following information regarding Dr. Jan's research: In contrast to most cellular mRNAs, many viruses have mechanisms that can bypass the need for cap-dependent translational initiation. This often involves RNA elements, called Internal Ribosome Entry Sites (IRES) that recruit ribosomal subunits to the RNA independent of many translation initiation factors. Dr Eric Jan has been investigating the mechanism of a very unusual IRES form the Cricket Paralysis Virus. Unlike previously studied IRESs, this IRES directly recruits 80S ribosomes without any canonical initiation factors or GTP hydrolysis. Moreover, the IRES does not initiate translation at an AUG codon in the ribosome P site nor does it require the initiator MET-tRNA, but instead initiates at an Alanine GCU codon in the ribosomal A site. Eric has used biochemistry to identify structural and sequence elements required for this interesting mode of translation initiation. He has also played a central role, by purifying and assembling the large number of required factors, in obtaining a 22A structure of the 40S/IRES complexes, and a 22A resolution of an 80S/IRES complex using cryoEM. Moreover, he has also identified putative cricket-like IRES elements in host cellular mRNAs, suggesting this mode of translational initiation may not be unique to the Cricket virus. In addition, these mRNAs are prime candidates for being translated with intitaitor tRNA levels are low in cells as is the case during angiogenesis, ischemia and apoptosis

July 22

12:00 Noon

Robert Oakley, Ph.D.
Senior Scientist
Norak Biosciences
Seminar Title: Recruitment of Arrestin Proteins to Activated GPCRs: A Novel Assay for Drug Discovery

Dr. Robert Oakley will be our second speaker in the series "Opportunities in Industry and Beyond." Dr. Oakley is a Senior Scientist at Norak Biosciences, a small biotech company in North Carolina. He will give a scientific talk on Tuesday, July 22nd and he will have lunch with all interested students following the talk. In addition, there will be two opportunities to intarct with Dr. Oakley on more individual bases: first, we will take him to dinner Mon. evening and second, we would like to set up small group meetings for Tues. morning. The idea for the small group meetings is to discuss their research and interests with Dr. Oakley and get his feedback as to the opportunities they might find in small biotech.

Alpha Yap, MD, PhD, Associate Professor, Institute for Molecular Bioscience and School for Biomedical Sciences, University of Queensland, Australia; Senior International Medical Research Fellow -Wellcome Trust
Passive No More: Cadherin Signaling and the Actin Cytoskeleton

Studant Host: S. Wilson

Albert B. Reynolds, PhD, Professor, Department of Cancer Biology, Vanderbilt University
A Core Function for p120-Catenin in Cadherin Regulation and Evidence of a Tumor Suppressor Role Student

Host: A. Doan

October 7

Fluno Center

Joseph Schlessinger, PhD, Professor and Chair, Department of Pharmacology, Yale University School of Medicine. Dr. Schlessinger is the Keynote Speaker for the Third Annual Signal Tranduction Research Training Symposium and the recipient of the Karl Beyer 2003 Professorship (This seminar will be held at the Fluno Center).
Cellular Signaling by Tyrosine Phosphorylation

Host: P. Keely

Sinisa Dovat, MD, Assistant Professor in Pediatric Hematology/Oncology, University of California-Los Angeles
The Role of Zinc Finger Genes in the Cell Cycle and in the Immune Response

Host: A. Ruoho

Danny Reinberg, PhD, Professor, Department of Biochemistry, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School
Chromatin and Its Impact on Gene Expression and Cellular Memory

Host: C. Kiekhaefer

Maik Huttemann, PhD, Assistant Professor, Research, Wayne State University School of Medicine, Molecular Medicine and Genetics
New isoforms of cytochrome c oxidase subunits and hypoxic induction of the lung-specific subunit IV gene.

Host: V. Bergendahl

John Condeelis, PhD, Professor and Co-Chair, Department of Anatomy and Structural Biology; ScientificDirector, Analytical Imaging Facility Albert Einstein College of Medicine
Identifying and Testing Genes Involved in Cell Motility During Metastasis

Host: C. Carbonara

November 17

Monday
10:15 am

Catherine Costello, Professor, Departments of Biochemistry and Biophysics; President, American Society for Mass Spectrometry, Boston University School of Medicine
New Mass Spectral Strategies for Proteomics and Glycomics (Note unusual day/time)

Host: J. Grant

Jeff Hardin – Zoology

Host: P. Keely

Timothy Gomez, PhD, Assistant Professor, Dynamic Nerve Growth Imaging Laboratory, Department of Anatomy, University of Wisconsin
Regulation of Growth Cone Motility by Calcium, Calpain and Src Family Tyrosine Kinase Signaling

Host: P. Keely

David M. Bodine, PhD, Chief, Hematopoiesis Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH
Dissecting the Regulatory Elements of Non-Globin Genes Expressed in Red Blood Cells

Host: E. Bresnick