Vladimir Spiegelman, M.D.,Ph.D. Assistant Professor of Dermatology spiegelman@dermatology.wisc.edu

Research Description:

My research effort is focused on the understanding of molecular pathways that lead to development of human malignancies, and employment of newly acquired knowledge for eradication of cancer. My current research program is focused on the mechanisms that govern the turnover of short-lived mRNAs that encode important tumorigenesis regulators and the implications of this turnover for tumor development.

Recent Publications: Articles on PubMed

• Elcheva I, Tarapore R, Bhatia N, Spiegelman VS.(2008). Overexpression of CRD-BP in malignant melanoma. Oncogene. In press.
  
  
• Bhatia N, Demmer TA., and Spiegelman VS. (2008). Inhibition of É¿-TrCP function potentiates UVB-induced apoptosis in hTERT-immortalized normal human keratinocytes. Photochem and Photobiol.84:376-381.
  
  
• Thiyagarajan S, Bhatia N, Reagan-Shaw S, Diana Cozma, Thomas-Tikhonenko A, Ahmad N, and Spiegelman VS. (2007). Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells. Cancer Res. 67:10642-10646.
  
  
• Syed DN, Afaq F, Kweon MH, Hadi N, Bhatia N, Spiegelman VS, Mukhtar H. (2007). Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-kappaB activation in normal human bronchial epithelial cells. Oncogene. 26:673-82.

• Saleem M, Kweon MH, Johnson JJ, Adhami VM, Elcheva I, Khan N, Bin Hafeez B, Bhat KM, Sarfaraz S, Reagan-Shaw S, Spiegelman VS, Setaluri V, and Mukhtar H. (2006). S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9. PNAS USA. 103:14825-14830. PDF PMID 16990429
  
  
• Noubissi FK, Elcheva I, Bhatia N, Shakoori A, Ougolkov A, Liu J, Minamoto T, Ross J, Fuchs SY, and Spiegelman VS. (2006). CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling. Nature. 441:898-901. PDF PMID 16778892
  
  
• Bhatia N, Thiyagarajan S, Elcheva I, Saleem M, Dlugosz A, Mukhtar H, and Spiegelman VS. (2006). Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase. J Biol Chem. 281:19320-19326. PDF PMID 16651270
  
  
• Li Y, Clevenger CV, Minkovsky N, Kumar KGS, Raghunath PN, Tomaszewski JE, Spiegelman VS, and Fuchs SY. (2005). Stabilization of prolactin receptor in breast cancer cells. Oncogene. 25:1896-1902. PDF PMID 16278670
  
  
• Bhatia N, Spiegelman VS. (2005). Activation of Wnt/beta-catenin/Tcf signaling in mouse skin carcinogenesis. Mol Carcinog. 42:213-221. PMID 15765534
  
  
• Tang W, Li Y, Yu D, Thomas-Tikhonenko A, Spiegelman VS, and Fuchs SY. (2005). Targeting beta-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells. Cancer Res. 65:1904-1908. PDF PMID 15753389
  
  
• Li Y, Kumar KG, Tang W, Spiegelman VS, and Fuchs SY. (2004). Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase. Mol Cell Biol. 24:4038-4048. PDF PMID 15082796

Invited Lectures

• 2007 - National Cancer Center Research Institute, Tokyo, Japan. Invited speaker
• 2007 - International Symposium on Tumor Biology, Kanazawa, Japan. Invited speaker
• 2005 - International Symposium on Diet in Causation and Prevention of Cancer. Lucknow, India. Invited speaker
• 2002 - Society of Toxicology 41st Annual Meeting. Nashville, TN. Invited speaker
• 2000 - International Skin Carcinogenesis Conference. Tuscon, AZ. Invited speaker

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