Michael N. Gould, Ph.D. Professor Department of Human Oncology and Medical Physics gould@oncology.wisc.edu Gould Lab Web Site

Our laboratory focus is in breast cancer research, including both basic and translational projects. Our three major projects are:

1) Breast cancer genetics: Initially, using animal models we are specifically looking for genes that prevent breast cancer. Once identified, these genes will provide a better understanding of the role of modifier genes in breast cancer risk and also provide anticancer drug development targets.

2) Oncogenes, Ras signaling: We are approaching two questions in the area of carcinogenesis -- How do H-Ras and K-Ras differ in their signaling pathways? Which of these pathways lead to organ specific carcinogenesis?

3) Breast cancer chemoprevention and therapy: Our laboratory is developing a novel class of anticancer drugs, the monoterpenes. They selectively induce apoptosis and inhibit proliferation in cancer cells. We are seeking the molecular basis of this important selectivity by investigating the effects of these drugs on cell cycle associated protein and signaling pathways associated with cytostasis and apoptosis. Additionally, we are performing studies with other potential chemopreventive agents, as well as identifying surrogate biomarkers for breast cancer risk.

Selected Publications: Articles on PubMed

• Bauer M, Eickhoff JC, Gould MN, Mundhenke C, Maass N, and Friedl A. (2007). Neutrophil gelatinase-associated lipocalin (NGAL) is a predictor of poor prognosis in human primary breast cancer. Breast Cancer Res Treat. PMID 17554627
  
  
• Samuelson DJ, Hesselson SE, Aperavich BA, Zan Y, Haag JD, Trentham-Dietz A, Hampton JM, Mau B, Chen KS, Baynes C, Khaw KT, Luben R, Perkins B, Shah M, Pharoah PD, Dunning AM, Easton DF, Ponder BA, and Gould MN. (2007). Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk. Proc Natl Acad Sci USA. 104:6299-6304. PMID 17404222
  
  
• Amos-Landgraf JM, Kwong LN, Kendziorski CM, Reichelderfer M, Torrealba J, Weichert J, Haag JD, Chen KS, Waller JL, Gould MN, and Dove WF. (2007). A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer. Proc Natl Acad Sci USA. 104:4036-4041. PMID 17360473
  
  
• Rose-Hellekant TA, Schroeder MD, Brockman JL, Zhdankin O, Bolstad R, Chen KS, Gould MN, Schuler LA, Sandgren EP. (2007). Estrogen receptor-positive mammary tumorigenesis in TGFalpha transgenic mice progresses with progesterone receptor loss. Oncogene. 26:5238-5246. PMID 17334393
  
  
• Cotroneo MS, Haag JD, Zan Y, Lopez CC, Thuwajit P, Petukhova GV, Camerini-Otero RD, Gendron-Fitzpatrick A, Griep AE, Murphy CJ, Dubielzig RR, and Gould MN. (2007). Characterizing a rat Brca2 knockout model. Oncogene. 26:1626-1635. PMID 16964288
  
  
• Woditschka S, Haag JD, Waller JL, Monson DM, Hitt AA, Brose HL, Hu R, Zheng Y, Watson PA, Kim K, Lindstrom MJ, Mau B, Steele VE, Lubet RA, and Gould MN. (2006). Neu-induced retroviral rat mammary carcinogenesis: a novel chemoprevention model for both hormonally responsive and nonresponsive mammary carcinomas. Cancer Res. 66:6884-6891. PDF PMID 16818667
  
  
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