Dr. David Thiriot

 

Pharmaceutical Research and Development
Biologics & Vaccines
Merck - West Point, Pennsylvania

david_thiriot@merck.com

Post-doctoral Fellow with Stanley Opella, University of California, 2001-2005

Graduate Education
Dr. Ruoho, Advisor at UW Madison 1995-2001
Info:

David has accepted a position at Merck (West Point, PA) in Pharmaceutical Research and Development, Biologics & Vaccines.

Recent Publications:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=Thiriot%2Bds

  • Thiriot DS, Nevzorov AA, and Opella SJ. (2005). Structural basis of the temperature transition of Pf1 bacteriophage. Protein Sci. 14:1064-1070. PDF PMID 15741342

  • Thiriot DS, Nevzorov AA, Zagyanskiy L, Wu CH, and Opella SJ. (2004). Structure of the coat protein in Pf1 bacteriophage determined by solid-state NMR spectroscopy. J Mol Biol. 341:869-879. PDF PMID 15288792

  • Mesleh MF, Lee S, Veglia G, Thiriot DS, Marassi F, and Opella SJ. (2003). Dipolar Waves Map the Structure and Topology of Helices in Membrane Proteins. J Am Chem Soc. 125:8928-8935. PDF PMID 12862490

  • Thiriot DS, Sievert MK, and Ruoho AE. (2002). Identification of Human Vesicle Monoamine Transporter (VMAT2) Lumenal Cysteines Which Form an Intramolecular Disulfide Bond. Biochem. 41:6346-6353. PDF PMID 12009896

  • Thiriot DS and Ruoho AE. (2001). Mutagenesis and Derivatization of Human VMAT2 Cysteines Identifies Transporter Domains Involved in Tetrabenazine Binding and Substrate Transport.  J Biol Chem. 276:27304-27315. PDF PMID 11375404

  • Wu Z, Thiriot DS, and Ruoho AE. (2001). Tyrosine 199 in Transmembrane Five of the b2-Adrenergic Receptor Interacts Directly with the Pharmacophore of a Unique Fluorenone-Based Antagonist.  Biochem. 354:485-491. PDF PMID 11237852

  • Rong Y, Arbabian M, Thiriot DS, Seibold A, Clark RB, and Ruoho AE. (1999). Probing the Salmeterol Binding Site on the b2-Adrenergic Receptor Using a Novel Photoaffinity Ligand, [125I]Iodoazidosalmeterol.  Biochem. 38:11278-11286. PDF PMID 10471277

  • Sievert MK, Thiriot DS, Edwards RH, and Ruoho AE. (1998). High-Efficiency Expression and Characterization of the Synaptic-Vesicle Monoamine Translocator from Baculovirus-Infacted Insect Cells. Biochem. 330:959-966. PDF PMID 9480916

Selected Poster/Meeting Abstracts:

  • Thiriot DS, Zeri A-C, Zagyanskiy L, Nevzorov A, Mesleh MF, and Opella SJ. (2003). Structural Studies of Filamentous Bacteriophage and Phage-Displayed Peptides by NMR Spectroscopy. FASEB Meeting in San Diego, CA. Faseb J. 17:A585.

  • Thiriot DS, Sievert MK, and Ruoho AE. (2003). Cysteine Mutagenesis of the Human Vesicle Monoamine Transporter (VMAT2) Identifies Ligand Binding Sites and a Disulfide Bond. FASEB Meeting in San Diego, CA. Faseb J. 17:A1026.

  • Thiriot DS, Sievert MK, and Ruoho AE. (2000). The Role of Native Cysteines in Synaptic Vesicle Monoamine Transporter (VMAT2) Ligand Binding and Monoamine Transport. FASEB Meeting in Boston, MA. Faseb J. 14:A1400.
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