Dr. Lloyd Lam

 

 

Senior Research Scientist

Abbott Laboratories

laml@mail.nih.gov

Graduate Education
Dr. Emery Bresnick, Advisor at UW Madison 1994-1999

Lloyd completed postdoctoral studies with Dr. Lou Staudt at the National Cancer Institute and is now a Senior Research Scientist, Abbott Laboratories. More information about Dr. Lam and his research can be found at: http://lymphochip.nih.gov/laml.html

Research Interests:

My research interest is to identify novel cancer therapeutic agents for lymphomas and leukemias and to study the molecular mechanism of these agents. The goal of these studies is to gain a better understanding in the regulation of gene expression and signaling pathways in normal and malignant lymphocytes.

Publications: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=Lam%2Blt
  • Lam LT, Wright G, Davis RE, Lenz G, Farinha P, Dang L, Chan JW, Rosenwald A, Gascoyne RD, and Staudt LM. (2008). Cooperative signaling through the STAT3 and NF-kappaB pathways in subtypes of diffuse large B cell lymphoma. Blood. PMID 18160665

  • Wan F, Anderson DE, Barnitz RA, Snow A, Bidere N, Zheng L, Hegde V, Lam LT, Staudt LM, Levens D, Deutsch WA, Lenardo MJ. (2007). Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation. Cell. 131:927-939. PMID 18045535

  • Dave SS, Fu K, Wright GW, Lam LT, Kluin P, Boerma EJ, Greiner TC, Weisenburger DD, Rosenwald A, Ott G, Muller-Hermelink HK, Gascoyne RD, Delabie J, Rimsza LM, Braziel RM, Grogan TM, Campo E, Jaffe ES, Dave BJ, Sanger W, Bast M, Vose JM, Armitage JO, Connors JM, Smeland EB, Kvaloy S, Holte H, Fisher RI, Miller TP, Montserrat E, Wilson WH, Bahl M, Zhao H, Yang L, Powell J, Simon R, Chan WC, and Staudt LM. (2006). Lymphoma/Leukemia Molecular Profiling Project. Molecular diagnosis of Burkitt's lymphoma. N Engl J Med. 354:2431-42. PDF PMID 16760443

  • Shaffer AL, Wright G, Yang L, Powell J, Ngo V, Lamy L, Lam LT, Davis RE, and Staudt LM. (2006). A library of gene expression signatures to illuminate normal and pathological lymphoid biology. Immunol Rev. 210:67-85. PDF PMID 16623765

  • Ngo VN, Davis RE, Lamy L, Yu X, Zhao H, Lenz G, Lam LT, Dave S, Yang L, Powell J, and Staudt LM. (2006) A loss-of-function RNA interference screen for molecular targets in cancer. Nature. 441:106-10. PDF PMID 16572121

  • Lam LT, Davis RE, Pierce J, Hepperle M, Xu Y, Hottelet M, Nong Y, Wen D, Adams J, Dang L, and Staudt LM. (2005). Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling. Clin Cancer Res. 11:28-40. PDF PMID 15671525

  • Lam LT and Bresnick EH. (2004). Gene array technology and the study of platelets and megakaryocytes. Methods Mol Biol. 273:479-490. PMID 15308819

  • Kovanen P, Rosenwald A, Hurt EM, Lam LT, Fu J, Staudt LM, and Leonard WJ. (2001). Expression monitoring reveals highly redundant gene responses to IL-2, IL-4, IL-7, and IL-15 and antigen receptor stimulation in lymphocytes. J Immunol. 278:5205-13. PDF PMID 12435740

  • Lam LT, Pickeral O, Peng AC, Rosenwald A, Hurt EM, Giltnane JM, Averett L, Zhao H, Davis RE, Sathyamoorthy M, Wahl E, Harris E, Mikovits J, Monks A, Hollingshead M, Sausville EA, and Staudt LM. (2001). Genomic-scale measurement of mRNA turnover using the anti-cancer drug flavopiridol. Genome Biol. 2:0041. PDF PMID 11597333

  • Lam LT, Ronchini C, Norton J, Capobianco AJ, and Bresnick EH. (2000). Suppression of erythroid but not megakaryocytic differentiation of human K562 erythroleukemic cells by Notch-1. J Biol Chem. 275:19676-19684. PDF PMID 10783395

  • Lam LT and Bresnick EH. (1998). Identity of the beta-globin locus control region binding protein HS2NF5 as the mammalian homolog of the Notch-regulated transcriptionfactor suppressor of hairless. J Biol Chem. 273:24223-24231. PDF PMID 9727046

  • Forsberg EC, Lam LT, Yang XJ, Nakatani Y, and Bresnick EH. (1997). Human histone acetyltransferase GCN5 exists in a stable macromolecular complex lacking the adapter ADA2. Biochem. 36:15918-15924. PDF PMID 9398325

  • Lam LT and Bresnick EH. (1996). A novel DNA-binding protein, HS2NF5, interacts with a functionally important sequence of the human beta-globin locus control region. J Biol Chem. 271:32421-32429. PDF PMID 8943307

  • Lam LT and Bresnick EH. (1995). Evidence for distinct DNA binding forms of the erythroid-specific transcription factor NF-E2. Biochem. 34:16347-16358. PMID 8845360

Awards:

  • 2000-present Cancer Research Training Award Fellow, Metabolism branch, National Cancer Institute, National Institutes of Health
See Lloyd's discovery on "New View of Cancer Treatment" that's highlighted on the ScienceNOW web site.

[Back to Alumni] [Home]