Dr. Jennifer E. Grant

 

Post-Doctoral Fellow

Center for Advanced Proteomics Research
MUSC Pharmacology
Charleston, South Carolina

jeg31@musc.edu

Post-doctoral Fellow in New Jersey 2006

Post-doctoral Fellow with Dr. Walker 2004-2006

Graduate Education
Dr. Arnold E. Ruoho, Advisor at UW Madison 1998-2004


Research Interests:

Structure and Function of G-Protein Signaling Cascades

Poster at Experimental Biology 2004
Crosslinking of Full-Length Intein-Derived PDEg Photoprobes to the Gat-GTPgS N-Terminus

J. E. Grant, L. Guo, M.M. Vestling, K.A. Martemyanov, V.A. Arshavsky, and A.E. Ruoho
Department of Pharmacology, University of Wisconsin Medical School Madison, 53706
Department of Chemistry, University of Wisconsin, Madison, 53706
Howe Laboratory of Opthamology, Harvard Medical School, Boston 02114

Publications:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=Grant%2Bje

  • Guo LW, Assadi-Porter FM, Grant JE, Wu H, Markley JL, and Ruoho AE.  (2007).      One-step purification of bacterially expressed recombinant transducin alpha-subunit and isotopically labeled PDE6 gamma-subunit for NMR analysis. Protein Expr Purif. 51:187-197. PMID 16938469

  • Geiser AH, Sievert MK, Guo LW, Grant JE, Krebs MP, Fotiadis D, Engel A, and Ruoho AE.  (2006).  Bacteriorhodopsin chimeras containing the third cytoplasmic loop of bovine rhodopsin activate transducin for GTP/GDP exchange.  Protein Sci. 15:1679-1690. PMID 16815918

  • Grant JE, Guo LW, Vestling MM, Kirill AM, Arshavsky VY, and Ruoho AE. (2006). The N-terminus of GTPgS-activated transducin b-subunit interacts with the C-Terminus of the cGMP phosphodiesterase b-subunit. J Biol Chem. 281:6194-6202. PDF PMID 16407279

  • Guo LW, Grant JE, Hajipour AR, Murdov, K, Arbabian M, Artemyev NO, and Ruoho AE. (2005). Asymmetric interaction between rod phosphodiesterase inhibitory b-subunits and the b- and b-catalytic subunits. J Biol Chem. 280:12585-12592. PDF PMID 15668239

  • Grant JE, Guo LW, Vestling MM, Martenyamov KA, Arshavsky VY, and Ruoho AE.  (2004). Crosslinking of full-length intein-derived PDEb photo-probes to the Gat -GTPbS N-terminus.  FASEB J. 18:A972 Suppl. S.

  • Assadi-Porter FM, Guo L, Abilgaard F, Grant JE, Ruoho AE, and Markley JL. (2003). Structural studies of the gamma-subunit of cGMP phosphodiesterase by NMR spectroscopy. FASEB J. 17:A638-A639

  • Guo L, Grant JE, Hajipour AR, Arbabian M, Granovsky A, Martemyanov K, Artemyev NO, Arshavsky VY, and Ruoho AE. (2003). Photoactivable PDEγ subunits: probes for identifying interactions in visual signal transduction. Exper Biol.

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