Dr. Renee Doughman (Dierckman)

 

Post-doctoral Fellow
with Dr. Keith Burridge

University of North Carolina - Chapel Hill

renee_doughman@med.unc.edu

Graduate Education
Dr. Richard A. Anderson, Advisor at UW Madison 1998-2003

Research Interests:

The role of the phosphoinositide phosphate kinases (PIPKs) in actin reorganization and cell motility

Renee defended her thesis on August 5, 2003. She conducted a short post-doc fellowship for Dr. Tom Martin here at the UW-Madison for one year. Now she is a postdoc fellow (Fall, 2004) in Dr. Keith Burridge's lab, Chapel Hill, North Carolina.

Proposed Dissertation Title: Functional diversity and local PI415P2 synthesis define type 1 phosphatidylinositol phosphate kinases.

Publications:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=Doughman%2Br
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=Dierckman%2Br

  • Burridge K and Doughman R. (2006). Front and back by Rho and Rac. Nat Cell Biol. 8:781-782. PDF PMID 16880807

  • Ling K, Doughman R, Iyer VV, Firestone AJ, Bairstow SF, Mosher DF, Shaler MD, and Anderson RA. (2003). Tyrosine phosphorylation of type-1a phosphatidylinositol phosphate inase by Src regulates an integrin-talin switch. J Cell Biol. 163:1339-1349. PDF PMID 14691141

  • Doughman R, Firestone A, and Anderson RA. (2003). Phosphatidylinositol phosphate kinases puts PIP2 in its place. J Memb Biol. 194:77-89. PDF PMID 14502432

  • Doughman R, Firestone A, Bunce MW, Wojtasiak M, and Anderson RA. (2003). Membrane ruffle formation requires coordination of Type Ia phospha-tidylinositol phosphate kinase and Rac signaling. J Biol Chem. 278:23036-23045. PDF PMID 12682053

  • Coppolino MG, Dierckman R, Loijens J, Collins R, Persaud M, Jangstra-Bilan, Trimble WS, Schreiben AD, Anderson RA, and Grinstein S. (2002). Indibition of Type 1 alpha phosphatidylinositiel - phosphate kinase impares localized actin remodeling - suppresses phagocytosis. J Biol Chem. 277:43849-4385. PDF PMID 12223494

  • Doughman R, Ling K, Firestone A, Bunce MW, and Anderson RA. (2002). Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature. 420:89-93. PDF PMID 12422220

  • Botelho RJ, Teruel M, Dierckman R, Anderson R, Wells A, York JD, Meyer T, and Grinstein S. (2001). Localized biphasic changes in phosphatidylinositol - 4, 5-bisphosphate at sites of phagocitosis. J Cell Biol. 151:1353-1367. PDF PMID 11134066

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