Dr. Monika Davare

Post-doctoral Fellow
with Dr. Thomas Soderling

Vollum Institute - Portland, Oregon

davarem@ohsu.edu

Graduate Education
Dr. Johannes Hell, Advisor at U.W. Madison 1996-2000

Research Interests: Neuronal Signaling involved in synaptic plasticity, gene transcription and neuronal survival.Calcium plays a vital role in neuronal signal transduction. In part, some of the downstream effects of increased intracellular calcium are mediated by calcium/calmodulin dependent protein kinases (CaMKs). CaMKs regulate multiple signaling pathways, including synaptic plasticity, gene expression, neuronal survival and cytoskeletal regulation. I am specifically investigating the role of the CaMKs in neuronal gene transcription and apoptosis using a variety of model systems.

Publications: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=Davare%2Bma

  • Hall DD, Davare MA, Shi M, Allen ML, Weisenhaus M, McKnight GS, and Hell JW. (2007). Critical role of cAMP-dependent protein kinase anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons.  Biochem. 46:1635-1646. PMID 17279627

  • Atkins CM, Davare MA, Oh MC, Derkach V, and Soderling TR. (2005). Bidirectional regulation of cytoplasmic polyadenylation element-binding protein phosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1 during hippocampal long-term potentiation. J Neurosci. 25:5604-5610. PDF PMID 15944388

  • Davare MA, Saneyoshi T, Guire ES, Nygaard SC, and Soderling TR. (2004). Inhibition of calcium/calmodulin-dependent protein kinase kinase by protein 14-3-3. J Biol Chem. 279:52191-52199. PDF PMID 15469938

  • Simon J, Arthur C, Fong AL, Dwyer JM, Davare MA, Reese E, Obrietan K, and Impey S. (2004). Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins. J Neurosci. 24:4324-4332. PDF PMID 15128846

  • Wayman GA, Kaech S, Grant WF, Davare MA, Impey S, Tokumitsu H, Nozaki N, Banker G, and Soderling TR. (2004). Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase I. J Neurosci. 24:3786-3794. PDF PMID 15084659

  • Davare MA and Hell JW. (2003). Increased phosphorylation of the neuronal L-type Ca(2+) channel Ca(v)1.2 during aging. PNAS USA. 100:16018-16023. PDF PMID 14665691

  • Davare MA, Avdonin V, Hall DD, Peden EM, Burette A, Weinberg RJ, Horne MC, Hoshi T, and Hell JW. (2001). A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2. Science. 293:98-101. Erratum in: Science. 293:804. PDF PMID 11441182

  • Valtschanoff JG, Burette A, Davare MA, Leonard AS, Hell JW, and Weinberg RJ. (2000). SAP97 concentrates at the postsynaptic density in cerebral cortex. Eur J Neurosci. 12:3605-3614. PDF PMID 11029631

  • Davare MA, Horne MC, and Hell JW. (2000). Protein phosphatase 2A is associated with class C L-type calcium channels (Cav1.2) and antagonizes channel phosphorylation by cAMP-dependent protein kinase. J Biol Chem. 275:39710-39717. PDF PMID 10984483

  • Davare MA, Dong F, Rubin CS, and Hell JW. (1999). The A-kinase anchor protein MAP2B and cAMP-dependent protein kinase are associated with class C L-type calcium channels in neurons. J Biol Chem. 274:30280-30287. PDF PMID 10514522

  • Leonard AS, Davare MA, Horne MC, Garner CC, and Hell JW. (1998). SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit. J Biol Chem. 273:19518-19524. PDF PMID 9677374