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Dr. Amit Bhatt
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Post Grad Trainee
UW Hospital Radiation Oncology
Medical Student, Rush Medical College
Graduate Education
Dr.
A. Huttenlocher, Advisor at UW Madison 1999-2002
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Info:
Amit K. Bhatt is a Post Graduate Trainee here at the UW-Madison Hospital and Clinics in the Department of Radiation Oncology. He graduated from Rush Medical School in Chicago, IL May 2006.
Research Interest:
Cell migration is a dynamic
process that requires the regulated turnover of adhesive complexes. Cell
adhesions are formed at the cell front that stabilize protrusions and
provide the traction necessary for translocation. Subsequently, actomyosin
based contraction provides the force by which the cell body can move forward.
Finally, a cell must release and disassemble adhesions at the rear to
allow for cell detachment. Despite recent progress the mechanisms that
regulate adhesive release at the cell rear remain poorly understood. My
project investigated the role of calpain in focal complex disassembly
and translocation using live imaging approaches.
Publications:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=Bhatt%2Bak
- Bhatt AK and Huttenlocher
A. (2003). Live cell imaging of molecular interactions at cell-substrate
contacts. Methods in Enzymol. 361:337-352. PMID 12624919
- Bhatt AK, Kaverina I,
Small JV, and Huttenlocher A. (2002). Regulation of focal complex
composition and disassembly by the calcium-dependent protease calpain.
J Cell Sci. 115:3415-3425. PDF PMID 12154072
- Lin B, Skidmore JM,
Bhatt A, Pfeffer SM, Pawloski L, and Maddock JR. (2001). Alanine
scan mutagenesis of the switch I domain of the Caulobacter crescentus
CgtA protein reveals critical amino acids required for in vivo function.
Mol Microbiol. 39:924-934. PDF PMID 11251813
- Dourdin N, Bhatt AK,
Dutt P, Greer PA, Arthur JS, Elce JS, and Huttenlocher A.
(2001). Reduced cell migration and disruption of the actin cytoskeleton
in calpain-deficient embryonic fibroblasts. J Biol Chem. 276:
48382-48388. PDF PMID 11602605
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