Pharmacology 875A: Antibiotics and Drug Discovery

• on target organelles
• on macromolecular synthesis
• as regulators of gene action

Genetics of resistance:

• positive and negative control mechanisms
• dominant and recessive resistance
• intrinsic and acquired resistance

Antibiotic discovery:

• harvesting biodiversity (actinomycetes, secondary metabolism)
• mechanism-based screening
• construction of reporter strains

Antibiotics as research tools