|
Dr, David Wassarman, 371 Medical Sciences
Center / 262-6648 / dawassarman@wisc.edu Wednesday/Friday 11:00-11:50, Room 108 Plant Sciences |
| Session number |
Date | Lecture topic | Reading-Weaver and papers | Homework questions/ answers |
Instructor |
|
1 |
Jan 21 | Orientation-course outline and goals | Sess. 1 | Wassarman/Ansari | |
| 2 | Jan 23 | Overview of gene expression mechanisms-Central dogma | Chapters 1-3, 1-57 | Sess. 2 | Wassarman |
| 3 | Jan 28 | RNA pol I and pol III transcription | Chapter 11, 325-338, Moss, Paule, Schramm | Sess. 3 | Wassarman |
| 4 | Jan 30 | RNA polymerases and gene promoters | Chapter 10, 261-294, Butler, Asturias | Sess. 4 | Ansari |
| 5 | Feb 4 | RNA pol II transcription-general transcription factors | Chapter 11, 297-324, Malik, Hochheimer, Tjian, Roeder | Sess. 5 | Ansari |
| 6 | Feb 6 | RNA pol II transcription-activators and repressors | Chapter 12, 342-377, Garvie, Darnell, Pandolfi | Sess. 6 | Ansari |
| 7 | Feb 11 | Chromatin/histone modification | Chapter 13, 380-415, Marmorstein | Sess. 7 | Wassarman |
| 8 | Feb 13 | Chromatin remodeling | Lusser, Iizuka, Rice | Sess. 8 | Wassarman |
| 9 | Feb 18 | Current topics in transcriptional regulation-Dosage compensation | Akhtar, Brockdorff | Sess. 9 | Wassarman |
| 10 | Feb 20 | Exam 1 | Exam 1 answers | Wassarman/Ansari | |
| 11 | Feb 25 | RNA processing-pre-mRNA splicing | Chapter 14, 418-450 | Sess. 11 | Wassarman |
| 12 | Feb 27 | RNA processing-capping and polyadenylation | Chapter 15, 462-494 | Sess. 12 | Wassarman |
| 13 | Mar 3 | RNA processing-rRNA, tRNA, trans-splicing, and RNA editing |
Chapter 14, 450-458 |
Sess. 13 | Wassarman |
| 14 | Mar 5 | Post-transcriptional regulation of mRNA-stability and transport | Wagner, Wilusz, Bentley | Sess. 14 | Wassarman |
| 15 | Mar 10 |
Current topics in the regulation of gene expression by RNA-RNA interference (RNAi/siRNA) | Chapter 14, 520-524 Hannon, Zamore |
Sess. 15 | Wassarman |
| 16 | Mar 12 | Translation-initiation | Chapter 17, 545-564 | Sess. 16 | Wassarman |
| Mar13-21 | Spring recess | ||||
| 17 | Mar 24 | Translation-elongation and termination | Chapter 18, 567-603 | Sess. 17 | Wassarman |
| 18 | Mar 26 | Ribosomes-structural considerations | Chapter 19, 606-625 Noller web site, http://rna.ucsc.edu/rnacenter/ |
Sess. 18 | Wassarman |
| 19 | Mar 31 | tRNA-regulatory and structural considerations | Chapter 19, 626-639 | Sess. 19 | Ansari |
| 20 | Apr 2 | Current topics in translational regulation-IRES | Pdfs | Sess. 20 | Seiser |
| 21 | Apr 7 | Exam 2 | Exam 2 answers | Wassarman/Ansari | |
| 22 | Apr 9 | DNA replication-basic mechanism | Chapter 20, 642-667 | Sess. 22 | Ansari |
| 23 | Apr 14 | DNA replication-initiation, elongation, and termination | Chapter 21, 684-708 | Sess. 23 | Ansari |
| 24 | Apr 16 | Centromeres and telomeres | Chapter 21, 708-716 | Sess. 24 | Ansari |
| 25 | Apr 21 | Current topics in DNA metabolism-origin recognition complex (ORC) | Stillman, Bell | Sess. 25 | Ansari |
| 26 | Apr 23 | DNA damage and repair | Chapter 20, 668-676 | Sess. 26 | Ansari |
| 27 | Apr 28 | Homologous recombination | Chapter 22, 717-745 | Sess. 27 | Ansari |
| 28 | Apr 30 | Site-specific recombination | Chapter 23, 747-767 | Sess. 28 | Ansari |
| 29 | May 5 | Genomes and applications of genomics | Chapter 24, 784-814 | Sess. 29 | Ansari |
| 30 | May 7 | Topics that integrate multiple mechanisms in eukaryotic molecular biology-NF-kB | Pdfs | Sess. 30 | Miyamoto |
| 31 | May 9-15 | Exam 3 | Exam 3 answers | Ansari |