501 Introduction to Biochemistry. 3 cr. Chemistry, nutrition, and metabolism of biological systems. Not accepted toward departmental M.S. or Ph.D. degree. P: Chem 341 or 343.
507 General Biochemistry I. 3-4 cr. Chemistry of biological materials, intermediary metabolism and protein structure. First semester of a year long first course in biochemistry. P: Chem 345. Honors stdts register for 4 cr, all others register for 3 cr.
508 General Biochemistry II. 3-4 cr. Chemistry and metabolism of nucleic acids and protein synthesis. Molecular and cellular biology. P: Biochem 507. Honors stdts register for 4 cr, all others register for 3 cr.
510 Biochemical Principles of Human and Animal Nutrition. (Crosslisted with Nutr Sci) 3 cr. Lectures in nutrition for students with a substantial background in biochemistry. Emphasis on biochemical and physiological fundamentals of nutrition. Discussion of protein, fat, carbohydrate, energy, minerals and vitamins and their roles and interrelationships in nutrition and metabolism. P: Biochem 501 or 602 or cons inst.
550 Topics in Medical Biochemistry. 2 cr Lectures. Biochemical and molecular analysis of selected human diseases. Topics will include lipid metabolism and atherosclerosis, cell cycle regulation and oncogene function in cancer, and human immunodeficiency virus (HIV) structure, life cycle, and mechanism of acquired immunodeficiency disease synsrome (Aids). P: Biochem 501, 507, or cons inst.
575 Biology of Viruses. (Crosslisted with MM&I) 2 cr. Lecture-discussion. Broad coverage of animal virology taught at molecular level. Topics include virus structure, viral replication/lifecycle, aspects of pathogenesis and prevention. P: Biocore 301/302, or AP score of 4 or 5 and Zoology 151 or 152; or MM&I 301.
601 Protein and Enzyme Structure and Function. 2 cr. Protein structure and dynamics. Protein folding. Physical organic chemistry of enzymatic catalysis. Analysis of enzyme kinetics and receptor-ligand interactions. Enzymatic reaction mechanisms. P: Biochem 501 or equiv, 1 sem phys chem, 1 yr org chem, & cons inst.
612 Prokaryotic Molecular Biology. (Crosslisted with Genetics, Microbio) 3 cr. Molecular basis of bacterial physiology and genetics with emphasis on molecular mechanisms; topics include nucleic acid-protein interactions, transcription, translation, replication, recombination, regulation of gene expression. P: Bact 370 or equiv & Biochem 501 or equiv, or cons inst.
621 Plant Biochemistry. (Crosslisted with Botany) 3 cr Lectures. Biochemistry of photosynthesis, respiration, and other metabolic and biosynthetic processes in plants. P: Biochem 501 or 602 or cons inst.
624 Mechanisms of Enzyme Action. 2 cr Lecture. The relation of structure and kinetics to mechanisms of enzymatic catalysis; studies of specific enzymes and enzyme systems. P: Biochem 501, or 507 & 508, or 601; Chem 561 or 565; or cons inst (not open to Fr).
625 Coenzymes and Cofactors in Enzymology. 2 cr. Course will emphasize the importance of coenzyme and cofactors of enzymes in biochemistry. All aspects of the biochemistry of coenzymes will be covered, including their biosynthesis as far as is known, the biochemical reactions they catalyze, their chemical and spectroscopic properties, and the mechanisms by which they facilitate biochemical reactions. P: Chem 343 & 344 or equiv, Biochem 501 or equiv, Chem 561 or 565 or equiv (may be taken concurrently).
630 Cellular Signal Transduction Mechanisms. (Crosslisted with Zoology, Phmcol-M) 3 cr. Lecture-discussion. Comprehensive coverage of human hormones, growth factors and other mediators; emphasis on hormone action and biosynthesis, cell biology of hormone-producing cells. P: Intro biochem (Biochem 501 or 507 & 508) & cell biology (Biocore 303 or Zool 570 or Path750) or cons inst.
636 Macromolecular Crystallography and Dynamics. 2 cr. Provide knowledge of techniques used to obtain detailed structural and dynamic information about biological macromolecules and survey results. Techniques include x-ray diffraction, electron microscopy and molecular dynamics simulations. Designed for advanced undergraduates and beginning graduate students in the biological sciences. P: Concurrent or prior biochem; calc, & freshman physics or equiv.
651 Biochemical Methods. 2 cr Lab. Introduction to modern biochemical laboratory techniques. For advanced undergraduates (biochemistry and other majors) and graduate students not majoring in biochemistry. P: Chem 221 and Biochem 501 or equiv.
660 Methods in Biochemistry. 2 cr. Survey of modern techniques in molecular biology and biochemistry. P: 2 sem organic chem, intermed or adv biochem/molec biol, & cons inst.
665 Biophysical Chemistry. (Crosslisted with Chem) 4 cr. Equilibrium thermodynamics, chemical kinetics and transport properties, with emphasis on solution behavior and application to noncovalent interactions of biological macromolecules in solution. For graduate students interested in the biological applications of physical chemistry. P: Grad st or cons inst. Stdts must meet prereqs for Chem 565 & have some prev background in phys chem.
703 Topics in Eukaryotic Regulation. (Crosslisted with Genetics) 2 cr. Design and interpretation of experiments addressing molecular mechanisms of eukaryotic regulation. For first year graduate students with firm knowledge of basic biochemistry, molecular biology and genetics. P: Biochem 612 or equiv & cons inst.
704 Chemical Biology. 2 cr. Chemistry and biology of proteins, nucleic acids and carbohydrates; application of organic chemistry to problems in cell biology, biotechnology, and biomedicine. P: Biochem 501 or equiv, 1 yr org chem & cons inst.
711 Sequence Analysis. (Crosslisted with Ahabs) 2 cr. Topics will include overviews of: RNA, DNA and protein structure; mechanisms of genetic change; sequence generation methods; comparison and alignment algorithms; motif recognition; 2D predictions; phylogeny calculations; database searching; discriminating coding criteria; phenotypic selection; phylogenic reconstruction. P: Grad st.
712 Sequence Analysis Laboratory. (Crosslisted with Ahabs) 1 cr. Topics will include: overview of Unix including file and directory management; introduction to sequence analysis; database searching; comparison methods; alignments; profiles and profile searching; pattern recognition; phylogenetic reconstruction; bibliographic information retrieval. P: Grad st; con reg in Biochem 711.
726 Regulation of Gene Expression in Prokaryotes. (Crosslisted with Microbio) 3 cr. An intensive examination of a limited number of systems to illustrate the range of molecular mechanism utilized to control gene expression in bacteria. P: Bact/Genetics/Biochem 612 or cons inst.
729 Advanced Topics. 1-3 cr. Specialized subjects of current interest. P: Cons inst.
799 Practicum in Biochemistry Teaching. 1-3 cr. P: Grad st & cons inst.
800 Practical Nuclear Magnetic Resonance Theory. 2 cr. Multiple pulse NMR, off-resonance effects, composite and shaped pulses, product operators, coherence transfer, one- and two-dimentional NMR, phase cycling, multiple quantum coherence, and cross relaxation. P: Cons inst.
801 Biochemical Applications of Nuclear Magnetic Resonance. 2 cr. Survey of current solution-state nuclear magnetic resonance techniques used in biochemical research; the emphasis will be on how data are acquired and on practical applications. P: Cons inst.
840 Regulatory Mechanisms in Plant Development. (Crosslisted with Botany, Genetics) 3 cr. Molecular mechanisms whereby endogenous and environmental regulatory factors control development; emphasis on stimulus perception and primary events in the signal chain leading to modulated gene expression and cellular development; lecture. P: Biochem 501 or 601 & Botany 500 or Biocore 301 & 323.
872 Selected Topics in Macromolecular and Biophysical Chemistry. (Crosslisted with Chem) 1-3 cr. P: Grad st.
875 Special Topics. 1-4 cr. P: Grad st and cons inst.
901 Seminar-Nutrition and Metabolism (Advanced). 1 cr. Presentation of original research results; discussion of recent articles in animal metabolism and nutrition. P: Cons inst.
902 Seminar-Plant Biochemistry (Advanced). 1 cr. Topics vary from semester to semester and will include bioenergetics in plants, plant metabolism, plant development, and molecular biology of plant systems. P: Cons inst.
905 Seminar-Biomolecular Structure (Advanced). 1 cr. Presentation from the original literature of recent developments in macromolecular structure and function. P: Cons inst.
907 Seminar-Molecular Genetics (Advanced). 1 cr. Research reports, special topics, and reports from recent literature in molecular genetics. P: Cons inst.
909 Seminar-Enzymology (Advanced). 1 cr. Research reports, special topics, and reports from recent literature in enzymology and enzyme mechanisms. P: Cons inst.
910 Seminar-Molecular Virology (Advanced). 1 cr. Research reports, special topics, and reports from recent literature in molecular virology. P: Cons inst.
911 Seminar-Molecular Mechanisms of Hormone Action (Advanced). 1 cr. To train students in evaluating published papers in regard to scientific merit and content; provide training in delivering an evaluation of this material to a large group; and to help students and faculty stay abreast of current developments in the area of steroid hormone action. P: Cons inst.
912 Seminar-Molecular Mechanisms of Development. 1 cr. Classical and current papers concerning molecular and genetic mechanisms of eukaryotic development will be presented and discussed. P: Cons inst.
913 Seminar-RiboGroup (Advanced). (Crosslisted with Bmolchem) 1 cr. Student-led discussions of Rna-related problems. P: Biochem 603 or equiv, Genetics 466 or equiv; cons inst.
914 Seminar-Molecular Biosciences (Advanced). (Crosslisted with Microbio, MM&I, Bmolchem) 1 cr. During the fall semester, molecular biosciences trainees who have not achieved dissertator status will present seminars based primarily on literature related to their projects. During the spring semester, molecular biosciences trainees with dissertator status will present seminars based upon their own research. P: Cons inst.
915 Computation and Informatics in Biology and Medicine. (Crosslisted with B M I, Genetics, BME, CBE, Comp Sci) 1 cr. Participants and outside speakers will discuss current research in computation and informatics in biology and medicine. This seminar is required of all Cibm program trainees. P: Cons inst.
916 Cellular Mechanisms of Protein Biogenesis and Trafficking. 1 cr. Recent literature relating to cellular aspects of the regulation of protein biogenesis including protein synthesis, folding, modification, degradation and trafficking, as well as function of molecular chaperones, will be presented and discussed. P: Cons inst.
932 Biotechnology Training Program Seminar. (Crosslisted with Microbio, CBE) 1 cr. Biotechnology Training Program trainees will present their research for critical review by audience. P: Grad st. Required of Biotechnology Training Program trainees.
945 Seminar-Chemical Biology (Advanced). (Crosslisted with Chem) 1 cr. Recent published esearch in chemical biology and related areas. Intended fo advanced graduate students, and required of all Nih Chemistry-Biology Interface trainees. P: Cons inst.
990 Research. 1-12 cr. P: Grad st & cons inst.