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Principal Research Interests

Education

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Michael W. Pariza

Professor, Department of Food Microbiology & Toxicology
Director, Food Research Institute
Wisconsin Distinguished Professor
University of Wisconsin–Madison
1925 Willow Drive
Madison, WI 53706–1187

telephone:   608-263-6955
fax:            608-263-1114
email:        mwpariza@wisc.edu

PRINCIPAL RESEARCH INTERESTS

Conjugated Linoleic Acid and Food

EDUCATION

BS 1967, Bacteriology, University of Wisconsin–Madison
MS 1969, Microbiology, Kansas State University
PhD 1973, Microbiology, Kansas State University
Postdoc, McArdle Laboratory for Cancer Research, University of Wisconsin–Madison

CURRENT RESEARCH PROJECTS

Dietary aspects of carcinogenesis.
Biological significance of conjugated linoleic acid (CLA).

RECENT PUBLICATIONS Search Pubmed for Publications Authored by Pariza, M.W.

Park Y, and M. W. Pariza. Mechanisms of body fat modulation by conjugated linoleic acid (CLA). (Review) Food Res. Internat. 40:311–323 (2007).
Park, Y., Y. L. Ha, and M. W. Pariza. pi-Complex formation of conjugated linoleic acid with iron. Food Chem. 100(3):972–976 (2007).

Li, G. M., D. Butz, B. Y. Dong, Y. Park, M. W. Pariza, and M. E. Cook. Selective conjugated fatty acids inhibit guinea pig platelet aggregation. European J. Pharmacol. 545(2–3):93–99 (2006).
Li, G. M., B. Y. Dong, D. E. Butz, Y. Park, M. W. Pariza, and M. E. Cook. NF-kappa B independent inhibition of lipopolysaccharide-induced cyclooxygenase by a conjugated linoleic acid cognate, conjugated nonadecadienoic acid. Biochim. Biophys. Acta Molec. Cell Biol. Lipids 1761(9):969–972 (2006).
Yurawecz, M. P., J. K. G. Kramer, O. Gudmundsen, M. W. Pariza, and S. Banni (eds.). Advances in Conjugated Linoleic Acid Research, Vol. 3, AOCS Press, Champaign, IL (2006).

Dhiman, T. R., S. Zaman, K. C. Olson, H. R. Bingham, A. L. Ure, and M. W. Pariza. Influence of feeding soybean oil on conjugated linoleic acid content in beef. J. Agric. Food Chem. 53(3):684–689 (2005).
Graves, E., A. Hitt, M. W. Pariza, M. E. Cook, and D. O. McCarthy, Conjugated linoleic acid preserves gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. Res. Nursing Health 28(1):48–55 (2005).
Park, Y., K. J. Albright, and M. W. Pariza. Effects of conjugated linoleic acid on long term feeding in Fischer 344 rats. Food Chem. Toxicol. 43(8):1273–1279 (2005).
Park, Y., J. M. Storkson, K. J. Albright, W. Liu and M. W. Pariza. Biological activities of conjugated fatty acids: conjugated eicosadienoic (conj. 20:2delta^{c11,t13/t12,c14}), eicosatrienoic (conj. 20:3delta^c8,t12,c14), and heneicosadienoic (conj. 21:2delta^{c12,t14/c13,t15}) acids and other metabolites of conjugated linoleic acid. Biochim. Biophys. Acta 1687:120–129 (2005).
Storkson, J. M., Y. Park, M. E. Cook, and M. W. Pariza. Effects of trans-10,cis-12 conjugated linoleic acid and cognates on apolipoprotein B secretion in HepG2 cells. Nutr. Res. 25(4):387–399 (2005).

Kang, K., M. Miyazaki, J. M. Ntambi, M. W. Pariza. Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity. Biochem. Biophys. Res. Commun. 315(3):532–537 (2004).
Pariza, M. W. Perspective on the safety and effectiveness of conjugated linoleic acid. Am. J. Clin. Nutr. 79(Suppl):1132S–1136S (2004).
Park Y., J. M. Storkson, W. Liu, K. J. Albright, M. E. Cook, and M. W. Pariza. Structure–activity relationship of conjugated linoleic acid and its cognates in inhibiting heparin-releasable lipoprotein lipase and glycerol release from fully differentiated 3T3-L1 adipocytes. J. Nutr. Biochem. 15(9):561–568 (2004).

Brown, J.M., M. S. Boysen, S. S. Jensen, R. F. Morrison, J. Storkson, R. Lea-Currie, M. Pariza, S. Mandrup, and M. K. McIntosh. Isomer-specific regulation of metabolism and PPAR gamma signaling by CLA in human preadipocytes. J. Lipid Res. 44(7):1287–1300 (2003).
Kang, K.H., W. Liu, K. J. Albright, Y. Park, and M. W. Pariza. trans-10,cis-12 CLA inhibits differentiation of 3T3-L1 adipocytes and decreases PPAR gamma expression. Biochem. Biophys. Res. Commun. 303(3):795–799 (2003).
Pariza, M. W., Y. Park, X. Xu, J. Ntambi, and K. Kang. Chapter 14: Speculation on the mechanisms of action of conjugated linoleic acid, pp. 251–258. In: Advances in Conjugated Linoleic Acid Research, Vol. 2. J. L. Sebedio, W. W. Christie, and R. Adlof (eds.), AOCS Press, Champaign, IL (2003).
Xu XF, Storkson J, Kim SH, Sugimoto K, Park Y, Pariza MW. Short-term intake of conjugated linoleic acid inhibits lipoprotein lipase and glucose metabolism but does not enhance lipolysis in mouse adipose tissue. J. Nutr. 133(3):663–667 (2003).

Choi, Y., Y. Park, J. M. Storkson, M. W. Pariza, and J. M. Ntambi. Inhibition of stearoyl-CoA desaturase activity by the cis-9, trans-11 isomer and the trans-10, cis-12 isomer of conjugated linoleic acid in MDA-MB-231 and MCF-7 human breast cancer cells. Biochem. Biophys. Res. Commun. 294:785-790 (2002).
Doyle, M. E., and M. W. Pariza. Antioxidant nutrients and protection from free radicals. pp. 1–30. In: Nutritional Toxicology, Second Edition. F. N. Kotsonis and M. A. Mackey (eds.). Taylor & Francis, New York (2002).
Kim, M. R., Y. Park, K. J. Albright, and M. W. Pariza. Differential responses of hamsters and rats fed high-fat or low-fat diets supplemented with conjugated linoleic acid. Nutr. Res. 22:715-722 (2002).
Ntambi, J. M., Y. Choi, Y. Park, J. M. Peters, and M. W. Pariza. Effects of conjugated linoleic acid (CLA) on immune responses, body composition and stearoyl-CoA desaturase. Can. J. Appl. Physiol. 27(6):617–627 (2002).
Pariza, M. W. Conjugated linoleic acid may be useful in treating diabetes by controlling body fat and weight gain. Diabetes Technol. Therap. 4:335-338 (2002).
Whigham, L.D., A. Higbee, D. E. Bjorling, Y. H. Park, M. W. Pariza, and M. E. Cook. Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs. Am. J. Physiol.–Regul. Integrative Comp. Physiol. 282(4):R1104–R1112 (2002).

Aydin, R., M. W. Pariza, and M. E. Cook. Olive oil prevents the adverse effects of dietary conjugated linoleic acid on chick hatchability and egg quality. J. Nutr. 131:800–806 (2001).
Choi, Y.J., Y. Park, M. W. Pariza MW, and J. M. Ntanbi. Regulation of stearoyl-CoA desaturase activity by the trans-10,cis-12 isomer of conjugated linoleic acid in HepG2 cells. Biochem. Biophys. Res. Commun. 284:689–693 (2001).
Doyle, M. E., and M. W. Pariza. Foodborne microbial pathogens and the Food Research Institute. Appl. Microbiol. 49:143–161 (2001).
Doyle, M. E., and M. W. Pariza. Chapter 1: Antioxidant nutrients and protection from free radicals. pp. 1–30. In: Nutritional Toxicology, Second Edition. F. N. Kotsonis and M. A. Mackey (eds.). Taylor & Francis, London and New York (2001).
Evans, M., Y. Park, M. Pariza, L. Curtis, B. Kuebler, and M. McIntosh. trans-10,cis-12 conjugated linoleic acid reduces triglyceride content while differentially affecting peroxisome proliferator activated receptor gamma2 and aP2 expression in 3T3-L1 preadipocytes. Lipids 36:1223–1232 (2001).
Kang, K, and M. W. Pariza. trans-10, cis-12-conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 287:377–382 (2001).
Pariza, M. W., and E. A. Johnson. Evaluating the safety of microbial enzyme preparations used in food processing: Update for a new century. Regulat. Toxicol. Pharmacol. 33:173–186 (2001).
Pariza, M. W., Y. Park, and M. E. Cook. The biologically active isomers of conjugated linoleic acid. Prog. Lipid Res. 40:283–298 (2001).
Park, Y. and M. W. Pariza. The effects of dietary conjugated nonadecadienoic acid on body composition in mice. Biochim. Biophys. Acta 1533:171–174 (2001).
Park, Y., and M. W. Pariza. Lipoxygenase inhibitors inhibit heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes and enhance body fat reduction in mice by conjugated linoleic acid. Biochim. Biophys. Acta 1534:27–33 (2001).
Park, Y., K. J. Albright, Z. Y. Cai, and M. W. Pariza. Comparison of methylation procedures for conjugated linoleic acid and artifact formation by commercial (trimethylsilyl)diazomethane. J. Agric. Food Chem. 49:1158–1164 (2001).
Peters, J. M., Y. Park, F. J. Gonzalez, and M. W. Pariza. Influence of conjugated linoleic acid (CLA) in peroxisome proliferator-activated receptor a (PPARa)-null mice. Biochim. Biophys. Acta 1533:233–242 (2001).
Stahl, J. L., E. B. Cook, M. A.[sic] Pariza, M. E. Cook, and F. M. Graziano. Effect of L-tryptophan supplementation on eosinophils and eotaxin in guinea pigs. Exp. Biol. Med. 226:177–184 (2001).
Whigham, L. D., E. B. Cook, J. L. Stahl, R. Saban, D. E. Bjorling, M. W. Pariza, and M. E. Cook. CLA reduces antigen-induced histamine and PGE(2) release from sensitized guinea pig tracheae. Am. J. Physiol. Reg. 280:R908–R912 (2001).

Choi, Y. J., Y. C. Kim, Y. B. Han, Y. Park, M. W. Pariza, and J. M. Ntambi. The trans-10,cis-12 isomer of conjugated linoleic acid downregulates stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes. J. Nutr. 130:1920–1924 (2000).
Dhiman, T. R., L. D. Satter, M. W. Pariza, M. P. Galli, K. Albright, and M. X. Tolosa. Conjugated linoleic acid (CLA) content of milk from cows offered diets rich in linoleic and linolenic acid. J. Dairy Sci. 83:1016–1027 (2000).
Ohshita, K., Y. Nakajima, J. Yamakoshi, S. Kataoka, M. Kikuchi, and M. W. Pariza. Safety evaluation of yeast glutaminase. Food Chem. Toxicol. 38:610–670 (2000).
Pariza, M. W., and Y. Park. Conjugated linoleic acid, lipid metabolism and adipocytes. In: Adipocyte Biology and Hormone Signaling. J. M. Ntambi (ed.), IOS Press, Tokyo, Japan. Pp. 159–164 (2000).
Pariza, M. W., Y. Park, and M. E. Cook. Mechanisms of action of conjugated linoleic acid: evidence and speculation. Proc. Soc. Exp. Biol. Med. 223:8–13 (2000).
Pariza, M. W. Food safety and biotechnology. In: The Cambridge World History of Food, Vol. 2. K. F. Kiple and K. C. Ornelas (eds.), Cambridge University Press, New York, NY. Pp. 1662–1667 (2000).
Park, Y., J. M. Storkson, J. M. Ntambi, M. E. Cook, C. J. Sih, and M. W. Pariza. Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10,cis-12 conjugated linoleic acid and its derivatives. Biochim. Biophys. Acta 1486:285–292 (2000).
Yang, M. D., M. W. Pariza, and M. E. Cook. Dietary conjugated linoleic acid protects against end stage disease of systemic lupus erythematosus in the NZB/W F1 mouse. Immunopharmacol. Immunotoxicol. 22:433–449 (2000).

Cook, M. E., D. DeVoney, B. Drake, M. W. Pariza, L. Whigham, and M. Yang. In Advances in Conjugated Linoleic Acid Research, Vol. 1. M. P. Yurawecz, M. M. Mossoba, J. K. G. Kramer, M. W. Pariza, and G. J. Nelson (eds.). Champaign, IL, AOCS Press. Chapter 17, pp. 226–237 (1999).
Dhiman, T. R., E. D. Helmink, D. J. McMahon, R. L. Fife, and M. W. Pariza. Conjugated linoleic acid content of milk and cheese from cows fed extruded oilseeds. J. Dairy Sci. 82:412–419 (1999).
Dhiman, T. R., G. R. Anand, L. D. Satter, and M. W. Pariza. Conjugated linoleic acid content of milk from cows fed different diets. J. Dairy Sci. 82:2146–2156 (1999).
Pariza, M. W. The biological activities of conjugated linoleic acid. In Advances in Conjugated Linoleic Acid Research, Vol. 1. M. P. Yurawecz, M. M. Mossoba, J. K. G. Kramer, M. W. Pariza, and G. J. Nelson (eds.). Champaign, IL, AOCS Press. Chapter 2, pp. 12–20 (1999).
Pariza, M. W., Y. Park, and M. E. Cook. Conjugated linoleic acid and the control of cancer and obesity. Toxicol. Sci. 52(Suppl.):107–110 (1999).
Park, Y., J. M. Storkson, K. J. Albright, W. Liu, and M. W. Pariza. Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 34:235–241 (1999).
Park, Y., K. J. Albright, J. M. Storkson, W. Liu, M. E. Cook, and M. W. Pariza. Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids 34:243–248 (1999).
Yurawecz, M. P., M. M. Mossoba, J. K. G. Kramer, M. W. Pariza, and G. J. Nelson (eds.). Advances in Conjugated Linoleic Acid Research, Vol. 1. Champaign, IL, AOCS Press. (1999).

Cook M. E., and M. W. Pariza. The role of conjugated linoleic acid (CLA) in health. Int. Dairy J. 8:459–462 (1998).
Garcia, H. S., J. M. Storkson, M. W. Pariza, and C. G. Hill. Enrichment of butteroil with conjugated linoleic acid via enzymatic interesterification (acidolysis) reactions. Biotechnol. Lett. 20:393–395 (1998).
Lee, K. N., M. W. Pariza, and J. M. Ntambi. Conjugated linoleic acid decreases hepatic stearoyl-CoA desaturase mRNA expression. Biochem. Biophys. Res. Commun. 248:817–821 (1998).
Pariza, M. W., S. V. Ponakala, P. A. Gerlat, and S. Andress. Predicting the functionality of direct food additives. Food Technol. 52(11):56–60 (1998).
Park, Y. and M. W. Pariza. Evidence that commercial calf and horse sera can contain substantial amounts of trans-10,cis-12 conjugated linoleic acid. Lipids 33:817–819 (1998).

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