Jaehyuk Yu's Home Page

Principal Research Interests

Education

Current Research Projects

Recent Publications

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FRI Faculty

Jaehyuk Yu

Associate Professor
Department of Bacteriology and Department of Genetics

mailing address:
Food Research Institute
University of Wisconsin–Madison
1550 Linden Drive
Madison, WI 53706-1521

telephone:   608-262-4696
fax:            608-263-1114
email:         jyu1@wisc.edu

PRINCIPAL RESEARCH INTERESTS

Fungi and Mycotoxins: Molecular Genetics of Asexual Sporulation and Mycotoxin Biosynthesis in Filamentous Fungi.

EDUCATION

BS 1986, Seoul National University, Seoul, Korea; Microbiology
MS 1991, University of Wisconsin–Madison; Food Science
PhD 1995, University of Wisconsin–Madison; Genetics
Postdoc 1995–1998, Texas A&M University; Genetics

CURRENT RESEARCH PROJECTS

Regulatory mechanisms of sporulation and mycotoxin biosynthesis in Aspergillus and Fusarium species.
Molecular genetics and genomics of fungal growth, sporulation and mycotoxin production.
Signal transduction in filamentous fungi.

RECENT PUBLICATIONS Search Pubmed for Publications Authored by Yu, J-H

Etxebeste, O., M. Ni, A. Garzia, N.-J. Kwon, R. Fischer, R., J. H. Yu, E. A. Espeso, and U. Ugalde. Basic-zipper-type transcription factor FlbB controls asexual development in Aspergillus nidulans. Eukaryotic Cell 7:38–48 (2008).
Ni, M., and J.-H Yu. A novel regulator couples sporogenesis and trehalose biogenesis in Aspergillus nidulans. PLoS ONE 2(10):e970 doi:10.1371/journal.pone.0000970 (2007).
Yu, J.-H., and C. d’Enfert. Signal transduction in Aspergilli. In: The Aspergilli: Genomics, Medical Aspects, Biotechnology, and Research Methods, G. H. Goldman and S. A. Osmani (eds), CRC Press, FL. pp 87–102 (2007).
Lafon, A., K.-H. Han, J.-A. Seo, J.-H. Yu, and C. d’Enfert. G protein and cAMP-mediated signaling in aspergilli: a genomic perspective. Fungal Genetics Biology 43:490–502 (2006).
Mah, J.-H., and J.-H. Yu. Upstream and downstream regulation of asexual development in Aspergillus fumigatus. Eukaryotic Cell 5:1585–1595 (2006).
Seo, J.-A., Y. Guan, and J.-H. Yu. FluG-dependent asexual development in Aspergillus nidulans occurs via de-repression. Genetics 172:1535–1544 (2006).
Seo, J. A., and J. H. Yu. The phosducin-like protein PhnA is required for G beta gamma-mediated signaling for vegetative growth, developmental control, and toxin biosynthesis in Aspergillus nidulans. Eukaryotic Cell 5(2):400–410 (2006).
Yu, J. H. Heterotrimeric G protein signaling and RGSs in Aspergillus nidulans. J. Microbiol. 44:145–154 (2006).
Yu, J.-H., J.-H. Mah, and J.-A. Seo. Growth and developmental control in the model and pathogenic aspergilli. Eukaryotic Cell 5:1577–1584 (2006).
Galagan, J. E., Calvo, S. E., Cuomo, C., Ma, L. J., Wortman, J. R., Batzoglou, S., Lee, S. I., Basturkmen, M., Spevak, C. C., Clutterbuck, J., Kapitonov, V., Jurka, J., Scazzocchio, C., Farman, M., Butler, J., Purcell, S., Harris, S., Braus, G. H., Draht, O., Busch, S., D'Enfert, C., Bouchier, C., Goldman, G. H., Bell-Pedersen, D., Griffiths-Jones, S., Doonan, J. H., Yu, J., Vienken, K., Pain, A., Freitag, M., Selker, E. U., Archer, D. B., Penalva, M. A., Oakley, B. R., Momany, M., Tanaka, T., Kumagai, T., Asai, K., Machida, M., Nierman, W. C., Denning, D. W., Caddick, M., Hynes, M., Paoletti, M., Fischer, R., Miller, B., Dyer, P., Sachs, M. S., Osmani, S. A. and Birren, B. W. Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. Nature 438:1105–1115 (2005).
Lafon, A., J.-A. Seo, K.-H. Han, J.-H. Yu, and C. d'Enfert. The heterotrimeric G-protein GanB(alpha)-SfaD(beta)-GpgA(gamma) is a carbon source sensor involved in early cAMP-dependent germination in Aspergillus nidulans. Genetics 171:71–80 (2005).
Ni, M., S. Rierson, J.-A. Seo, and J.-H. Yu. The pkaB gene encoding the secondary PKA catalytic subunit has a synthetic lethal interaction with pkaA and plays overlapping and opposite roles in Aspergillus nidulans. Eukaryotic Cell 4:1465–1476 (2005).
Nierman, W. C., Pain, A., Anderson, M. J., Wortman, J. R., Kim, H. S., Arroyo, J., Berriman, M., Abe, K., Archer, D. B., Bermejo, C., Bennett, J., Bowyer, P., Chen, D., Collins, M., Coulsen, R., Davies, R., Dyer, P. S., Farman, M., Fedorova, N., Fedorova, N., Feldblyum, T. V., Fischer, R., Fosker, N., Fraser, A., Garcia, J. L., Garcia, M. J., Goble, A., Goldman, G. H., Gomi, K., Griffith-Jones, S., Gwilliam, R., Haas, B., Haas, H., Harris, D., Horiuchi, H., Huang, J., Humphray, S., Jimenez, J., Keller, N., Khouri, H., Kitamoto, K., Kobayashi, T., Konzack, S., Kulkarni, R., Kumagai, T., Lafton, A., Latge, J. P., Li, W. X., Lord, A., Majoros, W. H., May, G. S., Miller, B. L., Mohamoud, Y., Molina, M., Monod, M., Mouyna, I., Mulligan, S., Murphy, L., O'Neil, S., Paulsen, I., Penalva, M. A., Pertea, M., Price, C., Pritchard, B. L., Quail, M. A., Rabbinowitsch, E., Rawlins, N., Rajandream, M. A., Reichard, U., Renauld, H., Robson, G. D., de Cordoba, S. R., Rodriguez-Pena, J. M., Ronning, C. M., Rutter, S., Salzberg, S. L., Sanchez, M., Sanchez-Ferrero, J. C., Saunders, D., Seeger, K., Squares, R., Squares, S., Takeuchi, M., Tekaia, F., Turner, G., de Aldana, C. R. V., Weidman, J., White, O., Woodward, J., Yu, J. H., Fraser, C., Galagan, J. E., Asai, K., Machida, M., Hall, N., Barrell, B. and Denning, D. W. Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature 438:1151–1156 (2005).
Seo, J.-A., K.-H. Han, K.-H., and J.-H. Yu. Multiple roles of a heterotrimeric G protein gamma subunit in governing growth and development of Aspergillus nidulans. Genetics 171:81–89 (2005).
Yu, J.-H., and N. P. Keller. Regulation of secondary metabolism in filamentous fungi. Ann. Rev. Phytopathol. 43:437–458 (2005).
Chang, P. K., J. Yu, and J.-H. Yu. (2004). aflT, a MFS transporter-encoding gene located in the aflatoxin gene cluster, does not have a significant role in aflatoxin secretion. Fungal Genet. Biol. 41:911–920.
Han, K.-H., J.-A. Seo, and J.-H. Yu. (2004). A putative G protein-coupled receptor negatively controls sexual development in Aspergillus nidulans. Mol. Microbiol. 51:1333–1345.
Han, K.-H., J.-A. Seo, and J.-H. Yu. (2004). Regulators of G-protein signalling in Aspergillus nidulans: RgsA downregulates stress response and stimulates asexual sporulation through attenuation of GanB (G alpha) signalling. Mol. Microbiol. 53(2):529–540.
Seo, J.-A., Han, K.-H., and Yu, J.-H. (2004). The gprA and gprB genes encode putative G protein coupled receptors required for self-fertilization in Aspergillus nidulans. Mol. Microbiol. 53: 1611–1623.
Seo, J.-A. and J.-H. Yu. (2004). Toxigenic fungi and mycotoxins, In Mycology 22: Handbook of Industrial Mycology, Z. An (ed), Marcel Dekker, NY, pp. 689–721.
Yu, J.-H., Z. Hamari, K.-H. Han, J.-A. Seo, Y. Reyes-Domínguez, and C. Scazzocchio. (2004). Double-Joint PCR (DJ-PCR): a PCR-based molecular tool for gene manipulations in filamentous fungi. Fungal Genet. Biol. 41:973–981.
Seo, J.-A., Y. J. Guan, and J.-H. Yu. (2003). Suppressor mutations bypass the requirement of fluG for asexual sporulation and sterigmatocystin production in Aspergillus nidulans. Genetics 165(3):1083–1093.
Han, K.-H., K.-Y. Han, J.-H. Yu, K.-S. Chae, K.-Y. Jahng, and D.-M. Han. (2001). The nsdD gene encodes a putative GATA type transcription factor necessary for sexual development of Aspergillus nidulans. Mol. Microbiol. 41:299–309.
Yu, J.-H., and Adams, T. H. (1999). Filamentous fungi. pp. 417–434. In Manual of Industrial Microbiology and Biotechnology, A. L. Demain and J. E. Davies (eds.). ASM Press.
Rosen, S., Yu, J.-H., and Adams, T. H. (1999). The Aspergillus nidulans sfaD gene encodes a G protein beta subunit that is required for normal growth and repression of sporulation. EMBO J. 18:5592–5600.
Yu, J.-H., Rosen, S., and Adams, T. H. (1999). Extragenic suppressors of loss-of-function mutations in the Aspergillus F1bA RGS domain protein. Genetics 151:97–105.
Adams, T. H., and Yu, J.-H. (1998) Coordinate control of secondary metabolite production and asexual sporulation in Aspergillus nidulans. Curr. Opinion Microbiol. 1:674–677.
Adams, T. H., Wieser, J., and Yu, J.-H. (1998). Asexual sporulation in Aspergillus nidulans. Microbiol. Mol. Biol. Rev. 62:35–54.
Hicks, J. K., Yu, J.-H., Keller, N. P., and Adams, T. H. (1997). Aspergillus sporulation and mycotoxin production both require inactivation of the FadA G-alpha protein-dependent signaling pathway. EMBO J. 16:4916–4923.
Wieser, J., Yu, J.-H., and Adams, T. H. (1997). Dominant mutations affecting both sporulation and sterigmatocystin production in Aspergillus nidulans. Curr. Genet. 32:218–224.
Yu, J.-H., Wieser, J., and Adams, T. H. (1996). The Aspergillus F1bA domain protein antagonizes G protein signaling to block proliferation and allow sporulation. EMBO J. 15:5184–5190.
Yu, J.-H., Butchko, R. A. E., Fernandes, M., Keller, N. P., Leonard, T. J., and Adams, T.H. (1996). Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus. Curr. Genet. 29:549–555.
Brown, D. W., Yu, J.-H., Kelkar, H. S., Fernandes, M., Nesbitt, T. C., Keller, N. P., Adams, T. H., and Leonard, T. J. (1996). Twenty-five co-regulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans. Proc. Natl. Acad. Sci. USA 93:1418–1422.
Yu, J.-H., and Leonard, T. J. (1995). Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthase. J. Bacteriol. 177:4792–4800.
Yu, J.-H., and Chu, F. S. (1991). Immunochromatography of fusarochromanone mycotoxins. J. Assoc. Off. Anal. Chem. 74:655–660.
Yu, J.-H., Wei, R.-D., Mirocha. C. J. and Chu, F. S. (1990). Production and characterization of antibody against fusarochromanone. Food Agric. Immunol. 2:55–64.

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