Food Research Institute: CLA (conjugated linoleic acid) references

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for information on CLA contact Dr. Michael W. Pariza [ mwpariza@wisc.edu ]

References on Conjugated Linoleic Acid (CLA)
updated 14 April 2008

year of publication: | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | prior to 2000 |

2008
Analytical Methods	for detection of CLA and its isomers
Effect of Diet	and other conditions on CLA levels in animals and animal products
Food, CLA content
General Articles and Reviews	If review articles can fit into one other category, e.g. Food, then they are put into that category; if they cover material that would be in more than one category, then they will be here in "General"
Physiological Effects of CLA: ... in Human Studies; ... in Laboratory Animals, Companion Animals (pets); ... in Food/Farm Animals (ruminants, swine, poultry, fish); ... in Cell Cultures, In Vitro Studies	(includes fat/protein levels, anticarcinogenic effects, etc.):
Synthesis of CLA	in vitro, microbial, plant

added 4/14/2008: Physiological Effects of CLA in Farm Animals

Bauman DE, Perfield JW, Harvatine KJ, Baumgard LH. Regulation of fat synthesis by conjugated linoleic acid: Lactation and the ruminant model. J. Nutr. 138(2):403-409 (2008).
Fernandez-Figares I, Conde-Aguilera JA, Nieto R, Lachica M (Lachica, M.), Aguilera JF. Synergistic effects of betaine and conjugated linoleic acid on the growth and carcass composition of growing Iberian pigs. J. Anim. Sci. 86(1):102-111 (2008).
Huang Y, Schoonmaker JP, Bradford BJ, Beitz DC. Response of milk fatty acid composition to dietary supplementation of soy oil, conjugated linoleic acid, or both. J. Dairy Sci. 91(1):260-270 (2008).
Ramos A, Bandarra NM, Rema P, Vaz-Pires P, Nunes ML, Andrade AM, Cordeiro AR, Valente LMP. Time course deposition of conjugated linoleic acid in market size rainbow trout (Oncorhynchus mykiss) muscle. Aquaculture 274(2-4):366-374 (2008).
Yin JD, Shang XG, Li DF, Wang FL, Guan YF, Wang ZY. Effects of dietary conjugated linoleic acid on the fatty acid profile and cholesterol content of egg yolks from different breeds of layers. Poultry Sci. 87(2):284-290 (2008).

added 4/14/2008: Food

Costa P, Roseiro LC, Bessa RJB, Padilha M, Partidario A, de Almeida JM, Calkins CR, Santos C. Muscle fiber and fatty acid profiles of Mertolenga-PDO meat. Meat Sci. 78(4):502-512 (2008).
Jimenez M, Garcia HS, Beristain CI. Sensory evaluation of dairy products supplemented with microencapsulated conjugated linoleic acid (CLA). LWT-Food Sci. Technol. 41(6):1047-1052 (2008).
Or-Rashid MM, Odongo NE, Subedi B, Karki P, McBride BW. Fatty acid composition of yak (Bos grunniens) cheese including conjugated linoleic acid and trans-18 : 1 fatty acids. J. Agric. Food Chem. 56(5):1654-1660 (2008).
Park SY, Aw JE, Kim GB, Jung MY, Lee BH. Distribution and content of geometric isomers of conjugated linoleic acid in dairy foods from the Quebec province of Canada. Food Sci. Technol. 17(1):31-37 (2008).
Rehberger B, Butikofer U, Bisig W, Collomb M. Influence of a dry fractionation of butterfat on the content of fatty acids including conjugated linoleic acids. European Food Res. Technol. 226(3):627-632 (2008).
Shingfield KJ, Chilliard Y, Toivonen V, Kairenius P, Givens DI. Trans fatty acids and bioactive lipids in ruminant milk. Bioactive Components Milk 606:3-65 (2008).
Sierra V, Aldai N, Castro P, Osoro K, Coto-Montes A, Olivan M. Prediction of the fatty acid composition of beef by near infrared transmittance spectroscopy. Meat Sci. 78(3):248-255 (2008).

added 4/14/2008: Diet

AbuGhazaleh AA. Effect of fish oil and sunflower oil supplementation on milk conjugated linoleic acid content for grazing dairy cows. Anim. Feed Sci. Technol. 141(3-4):220-232 (2008).
AlZahal O, Odongo NE, Mutsvangwa T, Or-Rashid MM, Duffield TF, Bagg R, Dick P, Vessie G, McBride BW. Effects of monensin and dietary soybean oil on milk fat percentage and milk fatty acid profile in lactating dairy cows. J. Dairy Sci. 91(3):1166-1174 (2008).
Bernard L, Leroux C, Chilliard Y. Expression and nutritional regulation of lipogenic genes in the ruminant lactating mammary gland. Bioactive Components Milk 606:67-108 (2008).
Chantaprasarn N, Wanapat M. Effects of sunflower oil supplementation in cassava hay based-diets for lactating dairy cows. Asian-Australiasian J. Anim. Sci. 21(1):42-50 (2008).
Chen P, Ji P, Li SL. Effects of feeding extruded soybean, ground canola seed and whole cottonseed on ruminal fermentation, performance and milk fatty acid profile in early lactation-dairy cows. Asian-Australiasian J. Anim. Sci. 21(2):204-213 (2008).
De Noni I, Battelli G. Terpenes and fatty acid profiles of milk fat and "Bitto" cheese as affected by transhumance of cows on different mountain pastures. Food Chem. 109(2):299-309 (2008).
Duffield TF, Rabiee AR, Lean IJ. A meta-analysis of the impact of monensin in lactating dairy cattle. Part 2. Production effects. J. Dairy Sci. 91(4):1347-1360 (2008).
Flowers G, Ibrahim SA, AbuGhazaleh AA. Milk fatty acid composition of grazing dairy cows when supplemented with linseed oil. J. Dairy Sci. 91(2):722-730 (2008).
Gill RK, VanOverbeke DL, Depenbusch B, Drouillard JS, DiCostanzo A. Impact of beef cattle diets containing corn or sorghum distillers grains on beef color, fatty acid profiles, and sensory attributes. J. Anim. Sci. 86(4):923-935 (2008).
Gomez-Cortes P, Frutos P, Mantecon AR, Juarez M, de la Fuente MA, Hervas G. Milk production, conjugated linoleic acid content, and in vitro ruminal fermentation in response to high levels of soybean oil in dairy ewe diet. J. Dairy Sci. 91(4):1560-1569 (2008).
Gruffat D, Remond C, Durand D, Loreau O, Bauchart D. 9cis, 11trans conjugated linoleic acid (CLA) is synthesised and desaturated into conjugated 18 : 3 in bovine adipose tissues. Animal 2(4):645-652 (2008).
Juchem SO, Santos JEP, Cerri RLA, Chebel RC, Galvao KN, Bruno R, Depeters EJ, Scottb T, Thatcher WW, Luchini D. Effect of calcium salts of fish and palm oils on lactational performance of Holstein cows. Anim. Feed Sci. Technol. 140(1-2):18-38 (2008).
Kadegowda AKG, Piperova LS, Erdman RA. Principal component and multivariate analysis of milk long-chain fatty acid composition during diet-induced milk fat depression. J. Dairy Sci. 91(2):749-759 (2008).
Kim JH, Choi NJ, Park HG, Kim IH, Lee HG, Song MK, Whang KY, Kim YJ. Utilization of oil by-product from the purification process of conjugated linoleic acid as feeding supplements for the accumulation of conjugated linoleic acid in the egg yolk. Poultry Sci. 87(1):64-70 (2008).
Kucuk O, Hess BW, Rule DC. Fatty acid compositions of mixed ruminal microbes isolated from sheep supplemented with soybean oil. Res. Vet. Sci. 84(2):215-224 (2008). Diet
Kudrna V, Marounek M. Influence of feeding whole sunflower seed and extruded linseed on production of dairy cows, rumen and plasma constituents, and fatty acid composition of milk. Arch. Anim. Nutr. 62(1):60-69 (2008).
Lucas A, Coulon JB, Agabriel C, Chilliard Y, Rock E. Relationships between the conditions of goat's milk production and the contents of some components of nutritional interest in Rocamadour cheese. Small Ruminant Res. 74(1-3):91-106 (2008).
Luna P, Bach A, Juarez M, de la Fuente MA. Effect of a diet enriched in whole linseed and sunflower oil on goat milk fatty acid composition and conjugated linoleic acid isomer profile. J. Dairy Sci. 91(1):20-28 (2008).
Luna P, Bach A, Juarez M, de la Fuente MA. Influence of diets rich in flax seed and sunflower oil on the fatty acid composition of ewes' milk fat especially on the level of conjugated linoleic acid, n-3 and n-6 fatty acids. Internat. Dairy J. 18(1):99-107 (2008).
Martin D, Muriel E, Antequera T, Perez-Palacios T, Ruiz J. Fatty acid composition and oxidative susceptibility of fresh loin and liver from pigs fed conjugated linoleic acid in combination with monounsaturated fatty acids. Food Chem. 108(1):86-96 (2008).
Moate PJ, Chalupa W, Boston RC, Lean IJ. Milk fatty acids II: Prediction of the production of individual fatty acids in bovine milk. J. Dairy Sci. 91(3):1175-1188 (2008).
Moreno T, Keane MG, Noci F, Moloney AP. Fatty acid composition of M-Longissimus dorsi from Holstein-Friesian steers of New Zealand and European/American descent and from Belgian Blue x Holstein-Friesian steers, slaughtered at two weights/ages. Meat Sci. 78(3):157-169 (2008).
Nelson ML, Busboom JR, Ross CF, O'Fallon JV. Effects of supplemental fat on growth performance and quality of beef from steers fed corn finishing diets. J. Anim. Sci. 86(4):936-948 (2008).
Nuernberg K, Fischer A, Nuernberg G, Ender K, Dannenberger D. Meat quality and fatty acid composition of lipids in muscle and fatty tissue of Skudde lambs fed grass versus concentrate. Small Ruminant Res. 74(1-3):279-283 (2008).
Or-Rashid MM, Kramer JKG, Wood MA, McBride BW. Supplemental algal meal alters the ruminal trans-18 : 1 fatty acid and conjugated linoleic acid composition in cattle. J. Anim. Sci. 86(1):187-196 (2008).
Osborne VR, Radhakrishnan S, Odongo NE, Hill AR, McBride BW. Effects of supplementing fish oil in the drinking water of dairy cows on production performance and milk fatty acid composition. J. Anim. Sci. 86(3):720-729 (2008).
Sasikala-Appukuttan AK, Schingoethe DJ, Hippen AR, Kalscheur KF, Karges K, Gibson ML. The feeding value of corn distillers solubles for lactating dairy cows. J. Dairy Sci. 91(1):279-287 (2008).
Schmidt J, Husveth F, Sipocza J, Toth T, Fabian J. Dietary manipulations to increase the concentration of conjugated linoleic acid in milk. Acta Alimentaria 37(1):53-63 (2008).
Shingfield KJ, Arola A, Ahvenjarvi S, Vanhatalo A, Toivonen V, Griinari JM, Huhtanen P. Ruminal infusions of cobalt-EDTA reduce mammary Delta 9-desaturase index and alter milk fatty acid composition in lactating cows. J. Nutr. 138(4):710-717 (2008).
Tsiplakou E, Kominakis A, Zervas G. The interaction between breed and diet on CLA and fatty acids content of milk fat of four sheep breeds kept indoors or at grass. Small Ruminant Res. 74(1-3):179-187 (2008).
Uccioni AB, Antongiovanni M, Petacchi F, Mele M, Serra A, Secchiari P, Minieri S. Effect of dried or green herbage on vaccenic acid and conjugated linoleic acid production during in vitro rumen fermentation. Anim. Feed Sci. Technol. 140(1-2):207-213 (2008).
Van Dorland HA, Kreuzer M, Leuenberger H, Wettstein HR . Comparative potential of white and red clover to modify the milk fatty acid profile of cows fed ryegrass-based diets from zero-grazing and silage systems. J. Sci. Food Agric. 88(1):77-85 (2008).
Warren HE, Scollan ND, Enser M, Hughes SI, Richardson RI, Wood JD. Effects of breed and a concentrate or grass silage diet on beef quality in cattle of 3 ages. I: Animal performance, carcass quality and muscle fatty acid composition. Meat Sci. 78(3):256-269 (2008).
Yu LL, Wang RL, Zhang YZ, Kleemann DO, Zhu XP, Jia ZH. Effects of selenium supplementation on polyunsaturated fatty acid concentrations and antioxidant status in plasma and liver of lambs fed linseed oil or sunflower oil diets. Anim. Feed Sci. Technol. 140(1-2):39-51 (2008).

added 4/14/2008: General Articles and Review

Gereszek LJ, Coats JR, Beitz DC. Effects of dietary conjugated linoleie acid on European corn borer (Lepidoptera : Crambidae) survival, fatty acid profile, and fecundity. Ann. Entomological Soc. Am. 101(2):430-438 (2008).
Milanesi E, Nicoloso L, Crepaldi P. Stearoyl CoA desaturase (SCD) gene polymorphisms in Italian cattle breeds. J. Anim. Breeding Genetics 125(1):63-67 (2008).
Nagao K, Yanagita T. Bioactive lipids in metabolic syndrome. Progress Lipid Res. 47(2):127-146 (2008).
Wood JD, Enser M, Fisher AV, Nute GR, Sheard PR, Richardson RI, Hughes SI, Whittington FM. Fat deposition, fatty acid composition and meat quality: A review. Meat Sci. 78(4):343-358 (2008).

added 4/14/2008: Analytical

Blasko J, Kubinec R, Pavikova E, Krupcik J, Sojak L. On the chemometric deconvolution of gas chromatographically unseparated trans-7,cis-9, cis-9,trans-11 and trans-8,cis-10 octadecadienoic acid isomers in ewe and cow milks. J. Food Nutr. Res. 47(1):29-36 (2008).
Kramer JKG, Hernandez M, Cruz-Hernandez C, Kraft J, Dugan MER. Combining results of two GC separations partly achieves determination of all cis and trans 16 : 1, 18 : 1, 18 : 2 and 18 : 3 except CLA isomers of milk fat as demonstrated using ag-ion SPE fractionation. Lipids 43(3):259-273 (2008).
Uehara H, Suganuma T, Negishi S, Uda Y, Furukawa Y, Ueno S, Sato K. Physical properties of two isomers of conjugated linoleic acid. J. Am. Oil Chem. Sco. 85(1):29-36 (2008).

added 4/14/2008: Physiological Effects of CLA in Humans

Cherniack EP. Potential applications for alternative medicine to treat obesity in an aging population. Alternative Med. Rev. 13(1):34-42 (2008).
Diaz ML, Watkins BA, Li Y, Anderson RA, Campbell WW. Chromium picolinate and conjugated linoleic acid do not synergistically influence diet- and exercise-induced changes in body composition and health indexes in overweight women. J. Nutr. Biochem. 19(1):61-68 (2008).
Motard-Belanger A, Charest A, Grenier G, Paquin P, Chouinard Y, Lemieux S, Couture P, Lamarche B. Study of the effect of trans fatty acids from ruminants on blood lipids and other risk factors for cardiovascular disease. Am. J. Clin. Nutr. 87(3):593-599 (2008).

added 4/14/2008: Physiological Effects of CLA in Laboratory Animals

Bissonauth V, Chouinard PY, Marin J, Leblanc N, Richard D, Jacques H. Altered lipid response in hamsters fed cis-9,trans-11+trans-8,cis-10 conjugated linoleic acid mixture. Lipids 43(3):251-258 (2008).
Diniz YS, Santos PP, Assalin HB, Souza GA, Rocha KKHR, Ebaid GMX, Seiva FRF, Amauchi JF, Novelli Filho JLVB, Novelli ELB. Conjugated linoleic acid and cardiac health: Oxidative stress and energetic metabolism in standard and sucrose-rich diets. European J. Pharmacol. 579(1-3):318-325 (2008).
Kanwar RK, MacGibbon AK, Black PN, Kanwar JR, Rowan A, Vale M, Krissansen GW. Bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuates allergic airway disease in mice. Clin. Exp. Allergy 38(1):208-218 (2008).
Mandir N, Goodlad RA. Conjugated linoleic acids differentially alter polyp number and diameter in the Apc(min/+) mouse model of intestinal cancer. Cell Proliferation 41(2):279-291 (2008).
Nunes EA, Bonatto SJ, de Oliveira HHP, Rivera NLM, Maiorka A, Krabbe EL, Tanhoffer RA , Fernandes LC. The effect of dietary supplementation with 9-cis : 12-trans and 10-trans : 12-cis conjugated linoleic acid (CLA) for nine months on serum cholesterol, lymphocyte proliferation and polymorphonuclear cells function in Beagle dogs. Res. Veterinary Sci. 84(1):62-67 (2008).
Wendel AA, Purushotham A, Liu LF, Belury MA. Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice. J. Lipid Res. 49(1):98-106 (2008).

added 4/14/2008: Physiological Effects of CLA in Cell Cultures

Goua M, Mulgrew S, Frank J, Rees D, Sneddon AA, Wahle KWJ . Regulation of adhesion molecule expression in human endothelial and smooth muscle cells by omega-3 fatty acids and conjugated linoleic acids: Involvement of the transcription factor NF-kappa B? Prostaglandins Leukotrienes Essential Fatty Acids 78(1):33-43 (2008).
Kang JH, Yang MP. In vitro evaluation of the effect of trans-10, cis-12 conjugated linoleic acid on phagocytosis by canine peripheral blood polymorphonuclear neutrophilic leukocytes exposed to methylprednisolone sodium succinate. Am. J. Vet. Res. 69(4):494-500 (2008).
Kim YS, Cerbo RM, Hah CK, Bahn KN, Kim JO, Ha YL. Growth inhibition of osteosarcoma cell MG-63 by a mixture of trans,trans conjugated linoleic acid isomers: Possible mechanistic actions. J. Food Sci. 73(1):T7-T15 (2008).
Larsen AE, Cameron-Smith D, Crowe TC. Conjugated linoleic acid suppresses myogenic gene expression in a model of human muscle cell inflammation. J. Nutr. 138(1):12-16 (2008).
Miller JR, Siripurkpong P, Hawes J, Majdalawieh A, Ro HS, McLeod RS. The trans-10, cis-12 isomer of conjugated linoleic acid decreases adiponectin assembly by PPAR gamma-dependent and PPAR gamma-independent mechanisms. J. Lipid Res. 49(3):550-562 (2008).
Moon HS, Lee HG, Seo JH, Guo DD, Kim IY, Chung CS , Kim TG, Choi YJ, Cho CS. Lipolysis is stimulated by PEGylated conjugated linoleic acid through the cyclic adenosine monophosphate-independent signaling pathway in 3T3-L1 cells: Activation of MEK/ERK MAPK signaling pathway and hyper-secretion of adipo-cytokines. J. Cell. Physiol. 214(2):283-294 (2008).
Ringseis R, Gahler S, Eder K. Conjugated linoleic acid isomers inhibit platelet-derived growth factor-induced NF-kappa B transactivation and collagen formation in human vascular smooth muscle cells. European J. Nutr. 47(2):59-67 (2008).
Stachowska E, Baskiewicz-Masiuk M, Dziedziejko V, Gutowska L, Baranowska-Bosiacka I, Marchlewicz M, Dolegowska B, Wiszniewska B, Machalinski B, Chlubek D. Conjugated linoleic acid increases intracellular ROS synthesis and oxygenation of arachidonic acid in macrophages. Nutrition 24(2):187-199 (2008).
Viswanadha S, McGilliard ML, Gandour RD, Herbein JH. Alterations in CPT-1 mRNA and fatty acid profile in hepatic cell lines in response to treatment with t10,c12-or c9,t11-conjugated linoleic acid. European J. Lipid Sci. Technol. 110(1):16-22 (2008).

added 4/14/2008: Synthesis of CLA

Alim MA, Lee JH, Akoh CC, Choi MS, Jeon MS, Shin JA, Lee KT. Enzymatic transesterification of fractionated rice bran oil with conjugated linoleic acid: Optimization by response surface methodology. LWT Food Sci. Technol. 41(5)764-770 (2008).
Alim MA, Lee JH, Shin JA, Lee YJ, Choi MS, Akoh CC, Lee KT. Lipase-catalyzed production of solid fat stock from fractionated rice bran oil, palm stearin, and conjugated linoleic acid by response surface methodology. Food Chem. 106(2):712-719 (2008).
Barouh N, Piombo G, Goli T, Barea B, Pina M, Lago R, Villeneuve P. Enzymatic production of conjugated linoleic acid monoacylglycerols from dehydrated isomerized castor bean oil. J. Food Lipids 15(1):13-27 (2008).
Carriquiry M, Weber WJ, Baumgard LH, Crooker BA. In vitro biohydrogenation of four dietary fats. Anim. Feed Sci. Technol. 141(3-4):339-355 (2008).
Hamam F, Shahidi F. Incorporation of selected long-chain fatty acids into trilinolein and trilinolenin. Food Chem. 106(1):33-39 (2008).
Vu PL, Shin JA, Lee YJ, Nam HY, Lee JH, Akoh CC, Lee KT. Development and characterization of structured lipids containing capric and conjugated linoleic acids as functional dietary lipid molecules. Internat. J. Food Sci. Nutr. 59(2):95-104 (2008).

2008

Analytical Methods return to top

Blasko J, Kubinec R, Pavikova E, Krupcik J, Sojak L. On the chemometric deconvolution of gas chromatographically unseparated trans-7,cis-9, cis-9,trans-11 and trans-8,cis-10 octadecadienoic acid isomers in ewe and cow milks. J. Food Nutr. Res. 47(1):29-36 (2008).
Kramer JKG, Hernandez M, Cruz-Hernandez C, Kraft J, Dugan MER. Combining results of two GC separations partly achieves determination of all cis and trans 16 : 1, 18 : 1, 18 : 2 and 18 : 3 except CLA isomers of milk fat as demonstrated using ag-ion SPE fractionation. Lipids 43(3):259-273 (2008).
Uehara H, Suganuma T, Negishi S, Uda Y, Furukawa Y, Ueno S, Sato K. Physical properties of two isomers of conjugated linoleic acid. J. Am. Oil Chem. Sco. 85(1):29-36 (2008).

Effects of Diet and Other Conditions on CLA in Animals and Animal Products return to top

AbuGhazaleh AA. Effect of fish oil and sunflower oil supplementation on milk conjugated linoleic acid content for grazing dairy cows. Anim. Feed Sci. Technol. 141(3-4):220-232 (2008).
AlZahal O, Odongo NE, Mutsvangwa T, Or-Rashid MM, Duffield TF, Bagg R, Dick P, Vessie G, McBride BW. Effects of monensin and dietary soybean oil on milk fat percentage and milk fatty acid profile in lactating dairy cows. J. Dairy Sci. 91(3):1166-1174 (2008).
Bernard L, Leroux C, Chilliard Y. Expression and nutritional regulation of lipogenic genes in the ruminant lactating mammary gland. Bioactive Components Milk 606:67-108 (2008).
Chantaprasarn N, Wanapat M. Effects of sunflower oil supplementation in cassava hay based-diets for lactating dairy cows. Asian-Australiasian J. Anim. Sci. 21(1):42-50 (2008).
Chen P, Ji P, Li SL. Effects of feeding extruded soybean, ground canola seed and whole cottonseed on ruminal fermentation, performance and milk fatty acid profile in early lactation-dairy cows. Asian-Australiasian J. Anim. Sci. 21(2):204-213 (2008).
De Noni I, Battelli G. Terpenes and fatty acid profiles of milk fat and "Bitto" cheese as affected by transhumance of cows on different mountain pastures. Food Chem. 109(2):299-309 (2008).
Duffield TF, Rabiee AR, Lean IJ. A meta-analysis of the impact of monensin in lactating dairy cattle. Part 2. Production effects. J. Dairy Sci. 91(4):1347-1360 (2008).
Flowers G, Ibrahim SA, AbuGhazaleh AA. Milk fatty acid composition of grazing dairy cows when supplemented with linseed oil. J. Dairy Sci. 91(2):722-730 (2008).
Gill RK, VanOverbeke DL, Depenbusch B, Drouillard JS, DiCostanzo A. Impact of beef cattle diets containing corn or sorghum distillers grains on beef color, fatty acid profiles, and sensory attributes. J. Anim. Sci. 86(4):923-935 (2008).
Gomez-Cortes P, Frutos P, Mantecon AR, Juarez M, de la Fuente MA, Hervas G. Milk production, conjugated linoleic acid content, and in vitro ruminal fermentation in response to high levels of soybean oil in dairy ewe diet. J. Dairy Sci. 91(4):1560-1569 (2008).
Gruffat D, Remond C, Durand D, Loreau O, Bauchart D. 9cis, 11trans conjugated linoleic acid (CLA) is synthesised and desaturated into conjugated 18 : 3 in bovine adipose tissues. Animal 2(4):645-652 (2008).
Juchem SO, Santos JEP, Cerri RLA, Chebel RC, Galvao KN, Bruno R, Depeters EJ, Scottb T, Thatcher WW, Luchini D. Effect of calcium salts of fish and palm oils on lactational performance of Holstein cows. Anim. Feed Sci. Technol. 140(1-2):18-38 (2008).
Kadegowda AKG, Piperova LS, Erdman RA. Principal component and multivariate analysis of milk long-chain fatty acid composition during diet-induced milk fat depression. J. Dairy Sci. 91(2):749-759 (2008).
Kim JH, Choi NJ, Park HG, Kim IH, Lee HG, Song MK, Whang KY, Kim YJ. Utilization of oil by-product from the purification process of conjugated linoleic acid as feeding supplements for the accumulation of conjugated linoleic acid in the egg yolk. Poultry Sci. 87(1):64-70 (2008).
Kucuk O, Hess BW, Rule DC. Fatty acid compositions of mixed ruminal microbes isolated from sheep supplemented with soybean oil. Res. Vet. Sci. 84(2):215-224 (2008). Diet
Kudrna V, Marounek M. Influence of feeding whole sunflower seed and extruded linseed on production of dairy cows, rumen and plasma constituents, and fatty acid composition of milk. Arch. Anim. Nutr. 62(1):60-69 (2008).
Lucas A, Coulon JB, Agabriel C, Chilliard Y, Rock E. Relationships between the conditions of goat's milk production and the contents of some components of nutritional interest in Rocamadour cheese. Small Ruminant Res. 74(1-3):91-106 (2008).
Luna P, Bach A, Juarez M, de la Fuente MA. Effect of a diet enriched in whole linseed and sunflower oil on goat milk fatty acid composition and conjugated linoleic acid isomer profile. J. Dairy Sci. 91(1):20-28 (2008).
Luna P, Bach A, Juarez M, de la Fuente MA. Influence of diets rich in flax seed and sunflower oil on the fatty acid composition of ewes' milk fat especially on the level of conjugated linoleic acid, n-3 and n-6 fatty acids. Internat. Dairy J. 18(1):99-107 (2008).
Martin D, Muriel E, Antequera T, Perez-Palacios T, Ruiz J. Fatty acid composition and oxidative susceptibility of fresh loin and liver from pigs fed conjugated linoleic acid in combination with monounsaturated fatty acids. Food Chem. 108(1):86-96 (2008).
Moate PJ, Chalupa W, Boston RC, Lean IJ. Milk fatty acids II: Prediction of the production of individual fatty acids in bovine milk. J. Dairy Sci. 91(3):1175-1188 (2008).
Moreno T, Keane MG, Noci F, Moloney AP. Fatty acid composition of M-Longissimus dorsi from Holstein-Friesian steers of New Zealand and European/American descent and from Belgian Blue x Holstein-Friesian steers, slaughtered at two weights/ages. Meat Sci. 78(3):157-169 (2008).
Nelson ML, Busboom JR, Ross CF, O'Fallon JV. Effects of supplemental fat on growth performance and quality of beef from steers fed corn finishing diets. J. Anim. Sci. 86(4):936-948 (2008).
Nuernberg K, Fischer A, Nuernberg G, Ender K, Dannenberger D. Meat quality and fatty acid composition of lipids in muscle and fatty tissue of Skudde lambs fed grass versus concentrate. Small Ruminant Res. 74(1-3):279-283 (2008).
Or-Rashid MM, Kramer JKG, Wood MA, McBride BW. Supplemental algal meal alters the ruminal trans-18 : 1 fatty acid and conjugated linoleic acid composition in cattle. J. Anim. Sci. 86(1):187-196 (2008).
Osborne VR, Radhakrishnan S, Odongo NE, Hill AR, McBride BW. Effects of supplementing fish oil in the drinking water of dairy cows on production performance and milk fatty acid composition. J. Anim. Sci. 86(3):720-729 (2008).
Sasikala-Appukuttan AK, Schingoethe DJ, Hippen AR, Kalscheur KF, Karges K, Gibson ML. The feeding value of corn distillers solubles for lactating dairy cows. J. Dairy Sci. 91(1):279-287 (2008).
Schmidt J, Husveth F, Sipocza J, Toth T, Fabian J. Dietary manipulations to increase the concentration of conjugated linoleic acid in milk. Acta Alimentaria 37(1):53-63 (2008).
Shingfield KJ, Arola A, Ahvenjarvi S, Vanhatalo A, Toivonen V, Griinari JM, Huhtanen P. Ruminal infusions of cobalt-EDTA reduce mammary Delta 9-desaturase index and alter milk fatty acid composition in lactating cows. J. Nutr. 138(4):710-717 (2008).
Tsiplakou E, Kominakis A, Zervas G. The interaction between breed and diet on CLA and fatty acids content of milk fat of four sheep breeds kept indoors or at grass. Small Ruminant Res. 74(1-3):179-187 (2008).
Uccioni AB, Antongiovanni M, Petacchi F, Mele M, Serra A, Secchiari P, Minieri S. Effect of dried or green herbage on vaccenic acid and conjugated linoleic acid production during in vitro rumen fermentation. Anim. Feed Sci. Technol. 140(1-2):207-213 (2008).
Van Dorland HA, Kreuzer M, Leuenberger H, Wettstein HR . Comparative potential of white and red clover to modify the milk fatty acid profile of cows fed ryegrass-based diets from zero-grazing and silage systems. J. Sci. Food Agric. 88(1):77-85 (2008).
Warren HE, Scollan ND, Enser M, Hughes SI, Richardson RI, Wood JD. Effects of breed and a concentrate or grass silage diet on beef quality in cattle of 3 ages. I: Animal performance, carcass quality and muscle fatty acid composition. Meat Sci. 78(3):256-269 (2008).
Yu LL, Wang RL, Zhang YZ, Kleemann DO, Zhu XP, Jia ZH. Effects of selenium supplementation on polyunsaturated fatty acid concentrations and antioxidant status in plasma and liver of lambs fed linseed oil or sunflower oil diets. Anim. Feed Sci. Technol. 140(1-2):39-51 (2008).

Food, CLA levels in return to top

Costa P, Roseiro LC, Bessa RJB, Padilha M, Partidario A, de Almeida JM, Calkins CR, Santos C. Muscle fiber and fatty acid profiles of Mertolenga-PDO meat. Meat Sci. 78(4):502-512 (2008).
Jimenez M, Garcia HS, Beristain CI. Sensory evaluation of dairy products supplemented with microencapsulated conjugated linoleic acid (CLA). LWT-Food Sci. Technol. 41(6):1047-1052 (2008).
Or-Rashid MM, Odongo NE, Subedi B, Karki P, McBride BW. Fatty acid composition of yak (Bos grunniens) cheese including conjugated linoleic acid and trans-18 : 1 fatty acids. J. Agric. Food Chem. 56(5):1654-1660 (2008).
Park SY, Aw JE, Kim GB, Jung MY, Lee BH. Distribution and content of geometric isomers of conjugated linoleic acid in dairy foods from the Quebec province of Canada. Food Sci. Technol. 17(1):31-37 (2008).
Rehberger B, Butikofer U, Bisig W, Collomb M. Influence of a dry fractionation of butterfat on the content of fatty acids including conjugated linoleic acids. European Food Res. Technol. 226(3):627-632 (2008).
Shingfield KJ, Chilliard Y, Toivonen V, Kairenius P, Givens DI. Trans fatty acids and bioactive lipids in ruminant milk. Bioactive Components Milk 606:3-65 (2008).
Sierra V, Aldai N, Castro P, Osoro K, Coto-Montes A, Olivan M. Prediction of the fatty acid composition of beef by near infrared transmittance spectroscopy. Meat Sci. 78(3):248-255 (2008).

General Articles and Reviews return to top

Gereszek LJ, Coats JR, Beitz DC. Effects of dietary conjugated linoleie acid on European corn borer (Lepidoptera : Crambidae) survival, fatty acid profile, and fecundity. Ann. Entomological Soc. Am. 101(2):430-438 (2008).
Milanesi E, Nicoloso L, Crepaldi P. Stearoyl CoA desaturase (SCD) gene polymorphisms in Italian cattle breeds. J. Anim. Breeding Genetics 125(1):63-67 (2008).
Nagao K, Yanagita T. Bioactive lipids in metabolic syndrome. Progress Lipid Res. 47(2):127-146 (2008).
Wood JD, Enser M, Fisher AV, Nute GR, Sheard PR, Richardson RI, Hughes SI, Whittington FM. Fat deposition, fatty acid composition and meat quality: A review. Meat Sci. 78(4):343-358 (2008).

Physiological Effects of CLA in Humans return to top

Cherniack EP. Potential applications for alternative medicine to treat obesity in an aging population. Alternative Med. Rev. 13(1):34-42 (2008).
Diaz ML, Watkins BA, Li Y, Anderson RA, Campbell WW. Chromium picolinate and conjugated linoleic acid do not synergistically influence diet- and exercise-induced changes in body composition and health indexes in overweight women. J. Nutr. Biochem. 19(1):61-68 (2008).
Motard-Belanger A, Charest A, Grenier G, Paquin P, Chouinard Y, Lemieux S, Couture P, Lamarche B. Study of the effect of trans fatty acids from ruminants on blood lipids and other risk factors for cardiovascular disease. Am. J. Clin. Nutr. 87(3):593-599 (2008).

Physiological Effects of CLA in Animals: Laboratory Animals, Companion Animals return to top

Bissonauth V, Chouinard PY, Marin J, Leblanc N, Richard D, Jacques H. Altered lipid response in hamsters fed cis-9,trans-11+trans-8,cis-10 conjugated linoleic acid mixture. Lipids 43(3):251-258 (2008).
Diniz YS, Santos PP, Assalin HB, Souza GA, Rocha KKHR, Ebaid GMX, Seiva FRF, Amauchi JF, Novelli Filho JLVB, Novelli ELB. Conjugated linoleic acid and cardiac health: Oxidative stress and energetic metabolism in standard and sucrose-rich diets. European J. Pharmacol. 579(1-3):318-325 (2008).
Kanwar RK, MacGibbon AK, Black PN, Kanwar JR, Rowan A, Vale M, Krissansen GW. Bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuates allergic airway disease in mice. Clin. Exp. Allergy 38(1):208-218 (2008).
Mandir N, Goodlad RA. Conjugated linoleic acids differentially alter polyp number and diameter in the Apc(min/+) mouse model of intestinal cancer. Cell Proliferation 41(2):279-291 (2008).
Nunes EA, Bonatto SJ, de Oliveira HHP, Rivera NLM, Maiorka A, Krabbe EL, Tanhoffer RA , Fernandes LC. The effect of dietary supplementation with 9-cis : 12-trans and 10-trans : 12-cis conjugated linoleic acid (CLA) for nine months on serum cholesterol, lymphocyte proliferation and polymorphonuclear cells function in Beagle dogs. Res. Veterinary Sci. 84(1):62-67 (2008).
Wendel AA, Purushotham A, Liu LF, Belury MA. Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice. J. Lipid Res. 49(1):98-106 (2008).

Physiological Effects of CLA in Animals: Food/Farm Animals return to top

Bauman DE, Perfield JW, Harvatine KJ, Baumgard LH. Regulation of fat synthesis by conjugated linoleic acid: Lactation and the ruminant model. J. Nutr. 138(2):403-409 (2008). Farm animals
Fernandez-Figares I, Conde-Aguilera JA, Nieto R, Lachica M (Lachica, M.), Aguilera JF. Synergistic effects of betaine and conjugated linoleic acid on the growth and carcass composition of growing Iberian pigs. J. Anim. Sci. 86(1):102-111 (2008). Farm animals
Huang Y, Schoonmaker JP, Bradford BJ, Beitz DC. Response of milk fatty acid composition to dietary supplementation of soy oil, conjugated linoleic acid, or both. J. Dairy Sci. 91(1):260-270 (2008). Farm animals
Ramos A, Bandarra NM, Rema P, Vaz-Pires P, Nunes ML, Andrade AM, Cordeiro AR, Valente LMP. Time course deposition of conjugated linoleic acid in market size rainbow trout (Oncorhynchus mykiss) muscle. Aquaculture 274(2-4):366-374 (2008). Farm animal
Yin JD, Shang XG, Li DF, Wang FL, Guan YF, Wang ZY. Effects of dietary conjugated linoleic acid on the fatty acid profile and cholesterol content of egg yolks from different breeds of layers. Poultry Sci. 87(2):284-290 (2008). Farm animals

Physiological Effects of CLA in Cell Cultures / In Vitro Studies return to top

Goua M, Mulgrew S, Frank J, Rees D, Sneddon AA, Wahle KWJ . Regulation of adhesion molecule expression in human endothelial and smooth muscle cells by omega-3 fatty acids and conjugated linoleic acids: Involvement of the transcription factor NF-kappa B? Prostaglandins Leukotrienes Essential Fatty Acids 78(1):33-43 (2008).
Kang JH, Yang MP. In vitro evaluation of the effect of trans-10, cis-12 conjugated linoleic acid on phagocytosis by canine peripheral blood polymorphonuclear neutrophilic leukocytes exposed to methylprednisolone sodium succinate. Am. J. Vet. Res. 69(4):494-500 (2008).
Kim YS, Cerbo RM, Hah CK, Bahn KN, Kim JO, Ha YL. Growth inhibition of osteosarcoma cell MG-63 by a mixture of trans,trans conjugated linoleic acid isomers: Possible mechanistic actions. J. Food Sci. 73(1):T7-T15 (2008).
Larsen AE, Cameron-Smith D, Crowe TC. Conjugated linoleic acid suppresses myogenic gene expression in a model of human muscle cell inflammation. J. Nutr. 138(1):12-16 (2008).
Miller JR, Siripurkpong P, Hawes J, Majdalawieh A, Ro HS, McLeod RS. The trans-10, cis-12 isomer of conjugated linoleic acid decreases adiponectin assembly by PPAR gamma-dependent and PPAR gamma-independent mechanisms. J. Lipid Res. 49(3):550-562 (2008).
Moon HS, Lee HG, Seo JH, Guo DD, Kim IY, Chung CS , Kim TG, Choi YJ, Cho CS. Lipolysis is stimulated by PEGylated conjugated linoleic acid through the cyclic adenosine monophosphate-independent signaling pathway in 3T3-L1 cells: Activation of MEK/ERK MAPK signaling pathway and hyper-secretion of adipo-cytokines. J. Cell. Physiol. 214(2):283-294 (2008).
Ringseis R, Gahler S, Eder K. Conjugated linoleic acid isomers inhibit platelet-derived growth factor-induced NF-kappa B transactivation and collagen formation in human vascular smooth muscle cells. European J. Nutr. 47(2):59-67 (2008).
Stachowska E, Baskiewicz-Masiuk M, Dziedziejko V, Gutowska L, Baranowska-Bosiacka I, Marchlewicz M, Dolegowska B, Wiszniewska B, Machalinski B, Chlubek D. Conjugated linoleic acid increases intracellular ROS synthesis and oxygenation of arachidonic acid in macrophages. Nutrition 24(2):187-199 (2008).
Viswanadha S, McGilliard ML, Gandour RD, Herbein JH. Alterations in CPT-1 mRNA and fatty acid profile in hepatic cell lines in response to treatment with t10,c12-or c9,t11-conjugated linoleic acid. European J. Lipid Sci. Technol. 110(1):16-22 (2008).

Synthesis: In vitro, Microbial, and Plant return to top

Alim MA, Lee JH, Akoh CC, Choi MS, Jeon MS, Shin JA, Lee KT. Enzymatic transesterification of fractionated rice bran oil with conjugated linoleic acid: Optimization by response surface methodology. LWT Food Sci. Technol. 41(5)764-770 (2008).
Alim MA, Lee JH, Shin JA, Lee YJ, Choi MS, Akoh CC, Lee KT. Lipase-catalyzed production of solid fat stock from fractionated rice bran oil, palm stearin, and conjugated linoleic acid by response surface methodology. Food Chem. 106(2):712-719 (2008).
Barouh N, Piombo G, Goli T, Barea B, Pina M, Lago R, Villeneuve P. Enzymatic production of conjugated linoleic acid monoacylglycerols from dehydrated isomerized castor bean oil. J. Food Lipids 15(1):13-27 (2008).
Carriquiry M, Weber WJ, Baumgard LH, Crooker BA. In vitro biohydrogenation of four dietary fats. Anim. Feed Sci. Technol. 141(3-4):339-355 (2008).
Hamam F, Shahidi F. Incorporation of selected long-chain fatty acids into trilinolein and trilinolenin. Food Chem. 106(1):33-39 (2008).
Vu PL, Shin JA, Lee YJ, Nam HY, Lee JH, Akoh CC, Lee KT. Development and characterization of structured lipids containing capric and conjugated linoleic acids as functional dietary lipid molecules. Internat. J. Food Sci. Nutr. 59(2):95-104 (2008).

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